Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vulnerable to TRX anti-oxidant pathway inhibition, an...

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Autores principales:	Christina M. Bebber, Emily S. Thomas, Jenny Stroh, Zhiyi Chen, Ariadne Androulidaki, Anna Schmitt, Michaela N. Höhne, Lukas Stüker, Cleidson de Pádua Alves, Armin Khonsari, Marcel A. Dammert, Fatma Parmaksiz, Hannah L. Tumbrink, Filippo Beleggia, Martin L. Sos, Jan Riemer, Julie George, Susanne Brodesser, Roman K. Thomas, H. Christian Reinhardt, Silvia von Karstedt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72d102a3804747f8993f740dde35ff92
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spelling	oai:doaj.org-article:72d102a3804747f8993f740dde35ff922021-12-02T14:21:15ZFerroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes10.1038/s41467-021-22336-42041-1723https://doaj.org/article/72d102a3804747f8993f740dde35ff922021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22336-4https://doaj.org/toc/2041-1723The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vulnerable to TRX anti-oxidant pathway inhibition, and the combination of these two treatments in SCLC circumvents non-NE/NE subtype plasticity.Christina M. BebberEmily S. ThomasJenny StrohZhiyi ChenAriadne AndroulidakiAnna SchmittMichaela N. HöhneLukas StükerCleidson de Pádua AlvesArmin KhonsariMarcel A. DammertFatma ParmaksizHannah L. TumbrinkFilippo BeleggiaMartin L. SosJan RiemerJulie GeorgeSusanne BrodesserRoman K. ThomasH. Christian ReinhardtSilvia von KarstedtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christina M. Bebber Emily S. Thomas Jenny Stroh Zhiyi Chen Ariadne Androulidaki Anna Schmitt Michaela N. Höhne Lukas Stüker Cleidson de Pádua Alves Armin Khonsari Marcel A. Dammert Fatma Parmaksiz Hannah L. Tumbrink Filippo Beleggia Martin L. Sos Jan Riemer Julie George Susanne Brodesser Roman K. Thomas H. Christian Reinhardt Silvia von Karstedt Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
description	The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vulnerable to TRX anti-oxidant pathway inhibition, and the combination of these two treatments in SCLC circumvents non-NE/NE subtype plasticity.
format	article
author	Christina M. Bebber Emily S. Thomas Jenny Stroh Zhiyi Chen Ariadne Androulidaki Anna Schmitt Michaela N. Höhne Lukas Stüker Cleidson de Pádua Alves Armin Khonsari Marcel A. Dammert Fatma Parmaksiz Hannah L. Tumbrink Filippo Beleggia Martin L. Sos Jan Riemer Julie George Susanne Brodesser Roman K. Thomas H. Christian Reinhardt Silvia von Karstedt
author_facet	Christina M. Bebber Emily S. Thomas Jenny Stroh Zhiyi Chen Ariadne Androulidaki Anna Schmitt Michaela N. Höhne Lukas Stüker Cleidson de Pádua Alves Armin Khonsari Marcel A. Dammert Fatma Parmaksiz Hannah L. Tumbrink Filippo Beleggia Martin L. Sos Jan Riemer Julie George Susanne Brodesser Roman K. Thomas H. Christian Reinhardt Silvia von Karstedt
author_sort	Christina M. Bebber
title	Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
title_short	Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
title_full	Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
title_fullStr	Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
title_full_unstemmed	Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
title_sort	ferroptosis response segregates small cell lung cancer (sclc) neuroendocrine subtypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72d102a3804747f8993f740dde35ff92
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Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

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