Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine

The present work describes the fabrication and electrochemical characterization of a novel iron oxide nanopowder-based carbon paste electrodes (CPE) for the sensitive voltammetric quantification of midodrine (MD) in pharmaceutical formulations and biological fluids. At the electrode surface, the pos...

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Autores principales:	Salhah D. Al-Qahtani, Ahmed Hameed, Enas Aljuhani, Reem Shah, Arwa Alharbi, Basim H. Asghar, Nashwa M. El-Metwaly
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Midodrine Iron oxide nanoparticles Carbon paste sensor Differential pulse voltammetry Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/72d21dd372f44fd69384943c37a9e70d
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spelling	oai:doaj.org-article:72d21dd372f44fd69384943c37a9e70d2021-11-20T04:58:05ZIron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine1878-535210.1016/j.arabjc.2021.103446https://doaj.org/article/72d21dd372f44fd69384943c37a9e70d2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221004615https://doaj.org/toc/1878-5352The present work describes the fabrication and electrochemical characterization of a novel iron oxide nanopowder-based carbon paste electrodes (CPE) for the sensitive voltammetric quantification of midodrine (MD) in pharmaceutical formulations and biological fluids. At the electrode surface, the postulated reaction mechanism involved the irreversible oxidation of the terminal amino group of midodrine through the participation of two-electron as elucidated by the sweep rate studies and molecular orbital calculations. Calibration graphs were linear in the MD concentration range from 0.16 × 10-6 to 2.12 × 10-6 mol L-1 with LOD 0.04 × 10-6 mol L-1. Prolonged stability with an operational lifetime of more than 4 months and high measurement reproducibility were the promising futures of the fabricated sensors. The proposed electroanalytical approach was free from interference and suggested for assaying of midodrine in its pharmaceutical formulations and biological samples with recovery agreed with the official methods.Salhah D. Al-QahtaniAhmed HameedEnas AljuhaniReem ShahArwa AlharbiBasim H. AsgharNashwa M. El-MetwalyElsevierarticleMidodrineIron oxide nanoparticlesCarbon paste sensorDifferential pulse voltammetryChemistryQD1-999ENArabian Journal of Chemistry, Vol 14, Iss 12, Pp 103446- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Midodrine Iron oxide nanoparticles Carbon paste sensor Differential pulse voltammetry Chemistry QD1-999
spellingShingle	Midodrine Iron oxide nanoparticles Carbon paste sensor Differential pulse voltammetry Chemistry QD1-999 Salhah D. Al-Qahtani Ahmed Hameed Enas Aljuhani Reem Shah Arwa Alharbi Basim H. Asghar Nashwa M. El-Metwaly Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine
description	The present work describes the fabrication and electrochemical characterization of a novel iron oxide nanopowder-based carbon paste electrodes (CPE) for the sensitive voltammetric quantification of midodrine (MD) in pharmaceutical formulations and biological fluids. At the electrode surface, the postulated reaction mechanism involved the irreversible oxidation of the terminal amino group of midodrine through the participation of two-electron as elucidated by the sweep rate studies and molecular orbital calculations. Calibration graphs were linear in the MD concentration range from 0.16 × 10-6 to 2.12 × 10-6 mol L-1 with LOD 0.04 × 10-6 mol L-1. Prolonged stability with an operational lifetime of more than 4 months and high measurement reproducibility were the promising futures of the fabricated sensors. The proposed electroanalytical approach was free from interference and suggested for assaying of midodrine in its pharmaceutical formulations and biological samples with recovery agreed with the official methods.
format	article
author	Salhah D. Al-Qahtani Ahmed Hameed Enas Aljuhani Reem Shah Arwa Alharbi Basim H. Asghar Nashwa M. El-Metwaly
author_facet	Salhah D. Al-Qahtani Ahmed Hameed Enas Aljuhani Reem Shah Arwa Alharbi Basim H. Asghar Nashwa M. El-Metwaly
author_sort	Salhah D. Al-Qahtani
title	Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine
title_short	Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine
title_full	Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine
title_fullStr	Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine
title_full_unstemmed	Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine
title_sort	iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/72d21dd372f44fd69384943c37a9e70d
work_keys_str_mv	AT salhahdalqahtani ironoxidenanopowderbasedelectrochemicalsensorforsensitivevoltammetricquantificationofmidodrine AT ahmedhameed ironoxidenanopowderbasedelectrochemicalsensorforsensitivevoltammetricquantificationofmidodrine AT enasaljuhani ironoxidenanopowderbasedelectrochemicalsensorforsensitivevoltammetricquantificationofmidodrine AT reemshah ironoxidenanopowderbasedelectrochemicalsensorforsensitivevoltammetricquantificationofmidodrine AT arwaalharbi ironoxidenanopowderbasedelectrochemicalsensorforsensitivevoltammetricquantificationofmidodrine AT basimhasghar ironoxidenanopowderbasedelectrochemicalsensorforsensitivevoltammetricquantificationofmidodrine AT nashwamelmetwaly ironoxidenanopowderbasedelectrochemicalsensorforsensitivevoltammetricquantificationofmidodrine
_version_	1718419721890562048

Iron oxide nanopowder based electrochemical sensor for sensitive voltammetric quantification of midodrine

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