Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging

Disruption of circadian rhythms leads to reduced healthspan, but the mechanisms by which the normal clock protects aging organisms are not known. Here, the authors show that a subset of genes becomes more rhythmically expressed in older flies, and these are enriched for response to oxidative stress.

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Autores principales:	Rachael C. Kuintzle, Eileen S. Chow, Tara N. Westby, Barbara O. Gvakharia, Jadwiga M. Giebultowicz, David A Hendrix
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72d2f017cdf647a7826f0fc41de1759f
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spelling	oai:doaj.org-article:72d2f017cdf647a7826f0fc41de1759f2021-12-02T17:06:16ZCircadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging10.1038/ncomms145292041-1723https://doaj.org/article/72d2f017cdf647a7826f0fc41de1759f2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14529https://doaj.org/toc/2041-1723Disruption of circadian rhythms leads to reduced healthspan, but the mechanisms by which the normal clock protects aging organisms are not known. Here, the authors show that a subset of genes becomes more rhythmically expressed in older flies, and these are enriched for response to oxidative stress.Rachael C. KuintzleEileen S. ChowTara N. WestbyBarbara O. GvakhariaJadwiga M. GiebultowiczDavid A HendrixNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rachael C. Kuintzle Eileen S. Chow Tara N. Westby Barbara O. Gvakharia Jadwiga M. Giebultowicz David A Hendrix Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
description	Disruption of circadian rhythms leads to reduced healthspan, but the mechanisms by which the normal clock protects aging organisms are not known. Here, the authors show that a subset of genes becomes more rhythmically expressed in older flies, and these are enriched for response to oxidative stress.
format	article
author	Rachael C. Kuintzle Eileen S. Chow Tara N. Westby Barbara O. Gvakharia Jadwiga M. Giebultowicz David A Hendrix
author_facet	Rachael C. Kuintzle Eileen S. Chow Tara N. Westby Barbara O. Gvakharia Jadwiga M. Giebultowicz David A Hendrix
author_sort	Rachael C. Kuintzle
title	Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
title_short	Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
title_full	Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
title_fullStr	Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
title_full_unstemmed	Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
title_sort	circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/72d2f017cdf647a7826f0fc41de1759f
work_keys_str_mv	AT rachaelckuintzle circadiandeepsequencingrevealsstressresponsegenesthatadoptrobustrhythmicexpressionduringaging AT eileenschow circadiandeepsequencingrevealsstressresponsegenesthatadoptrobustrhythmicexpressionduringaging AT taranwestby circadiandeepsequencingrevealsstressresponsegenesthatadoptrobustrhythmicexpressionduringaging AT barbaraogvakharia circadiandeepsequencingrevealsstressresponsegenesthatadoptrobustrhythmicexpressionduringaging AT jadwigamgiebultowicz circadiandeepsequencingrevealsstressresponsegenesthatadoptrobustrhythmicexpressionduringaging AT davidahendrix circadiandeepsequencingrevealsstressresponsegenesthatadoptrobustrhythmicexpressionduringaging
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Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging

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