Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF cooperativity and its functional consequences base...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ignacio L. Ibarra, Nele M. Hollmann, Bernd Klaus, Sandra Augsten, Britta Velten, Janosch Hennig, Judith B. Zaugg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72d38bbd5c5341449dcf400e10a51167
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:72d38bbd5c5341449dcf400e10a51167
record_format	dspace
spelling	oai:doaj.org-article:72d38bbd5c5341449dcf400e10a511672021-12-02T15:37:15ZMechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions10.1038/s41467-019-13888-72041-1723https://doaj.org/article/72d38bbd5c5341449dcf400e10a511672020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13888-7https://doaj.org/toc/2041-1723Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF cooperativity and its functional consequences based on next generation sequencing data and provide mechanistic insights into TF cooperativity and its impact on protein-phenotype interactions.Ignacio L. IbarraNele M. HollmannBernd KlausSandra AugstenBritta VeltenJanosch HennigJudith B. ZauggNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ignacio L. Ibarra Nele M. Hollmann Bernd Klaus Sandra Augsten Britta Velten Janosch Hennig Judith B. Zaugg Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
description	Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF cooperativity and its functional consequences based on next generation sequencing data and provide mechanistic insights into TF cooperativity and its impact on protein-phenotype interactions.
format	article
author	Ignacio L. Ibarra Nele M. Hollmann Bernd Klaus Sandra Augsten Britta Velten Janosch Hennig Judith B. Zaugg
author_facet	Ignacio L. Ibarra Nele M. Hollmann Bernd Klaus Sandra Augsten Britta Velten Janosch Hennig Judith B. Zaugg
author_sort	Ignacio L. Ibarra
title	Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
title_short	Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
title_full	Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
title_fullStr	Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
title_full_unstemmed	Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
title_sort	mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/72d38bbd5c5341449dcf400e10a51167
work_keys_str_mv	AT ignaciolibarra mechanisticinsightsintotranscriptionfactorcooperativityanditsimpactonproteinphenotypeinteractions AT nelemhollmann mechanisticinsightsintotranscriptionfactorcooperativityanditsimpactonproteinphenotypeinteractions AT berndklaus mechanisticinsightsintotranscriptionfactorcooperativityanditsimpactonproteinphenotypeinteractions AT sandraaugsten mechanisticinsightsintotranscriptionfactorcooperativityanditsimpactonproteinphenotypeinteractions AT brittavelten mechanisticinsightsintotranscriptionfactorcooperativityanditsimpactonproteinphenotypeinteractions AT janoschhennig mechanisticinsightsintotranscriptionfactorcooperativityanditsimpactonproteinphenotypeinteractions AT judithbzaugg mechanisticinsightsintotranscriptionfactorcooperativityanditsimpactonproteinphenotypeinteractions
_version_	1718386239702302720

Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

Ejemplares similares