Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF cooperativity and its functional consequences base...

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Autores principales: Ignacio L. Ibarra, Nele M. Hollmann, Bernd Klaus, Sandra Augsten, Britta Velten, Janosch Hennig, Judith B. Zaugg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/72d38bbd5c5341449dcf400e10a51167
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