Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia

Molecular mechanisms associated with human germ cell aplasia in infertile men remain undefined. Here the authors perform single-cell transcriptome profiling to highlight differentially expressed genes and pathways in each somatic cell type in testes of men with idiopathic germ cell aplasia.

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Autores principales:	Massimo Alfano, Anna Sofia Tascini, Filippo Pederzoli, Irene Locatelli, Manuela Nebuloni, Francesca Giannese, Jose Manuel Garcia-Manteiga, Giovanni Tonon, Giada Amodio, Silvia Gregori, Alessandra Agresti, Francesco Montorsi, Andrea Salonia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/72d44dea6e06424a96786fa8a4b23932
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spelling	oai:doaj.org-article:72d44dea6e06424a96786fa8a4b239322021-12-02T16:38:26ZAging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia10.1038/s41467-021-25544-02041-1723https://doaj.org/article/72d44dea6e06424a96786fa8a4b239322021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25544-0https://doaj.org/toc/2041-1723Molecular mechanisms associated with human germ cell aplasia in infertile men remain undefined. Here the authors perform single-cell transcriptome profiling to highlight differentially expressed genes and pathways in each somatic cell type in testes of men with idiopathic germ cell aplasia.Massimo AlfanoAnna Sofia TasciniFilippo PederzoliIrene LocatelliManuela NebuloniFrancesca GianneseJose Manuel Garcia-ManteigaGiovanni TononGiada AmodioSilvia GregoriAlessandra AgrestiFrancesco MontorsiAndrea SaloniaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Massimo Alfano Anna Sofia Tascini Filippo Pederzoli Irene Locatelli Manuela Nebuloni Francesca Giannese Jose Manuel Garcia-Manteiga Giovanni Tonon Giada Amodio Silvia Gregori Alessandra Agresti Francesco Montorsi Andrea Salonia Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
description	Molecular mechanisms associated with human germ cell aplasia in infertile men remain undefined. Here the authors perform single-cell transcriptome profiling to highlight differentially expressed genes and pathways in each somatic cell type in testes of men with idiopathic germ cell aplasia.
format	article
author	Massimo Alfano Anna Sofia Tascini Filippo Pederzoli Irene Locatelli Manuela Nebuloni Francesca Giannese Jose Manuel Garcia-Manteiga Giovanni Tonon Giada Amodio Silvia Gregori Alessandra Agresti Francesco Montorsi Andrea Salonia
author_facet	Massimo Alfano Anna Sofia Tascini Filippo Pederzoli Irene Locatelli Manuela Nebuloni Francesca Giannese Jose Manuel Garcia-Manteiga Giovanni Tonon Giada Amodio Silvia Gregori Alessandra Agresti Francesco Montorsi Andrea Salonia
author_sort	Massimo Alfano
title	Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
title_short	Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
title_full	Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
title_fullStr	Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
title_full_unstemmed	Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
title_sort	aging, inflammation and dna damage in the somatic testicular niche with idiopathic germ cell aplasia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72d44dea6e06424a96786fa8a4b23932
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Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia

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