Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix

Clostridioides difficile adenine methyltransferase A (CamA) is required for the sporulation and colonization of the pathogen that causes gastrointestinal infections. Here, the authors characterise CamA kinetically and present its crystal structure bound to the DNA recognition sequence, which reveals...

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Bibliographic Details
Main Authors: Jujun Zhou, John R. Horton, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/72d81f7c9e58495889a373df8da8fa71
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