Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil

Abstract Knowledge of infectious diseases in wildlife provides important information for preventing potential outbreaks of zoonotic diseases. Adiaspiromycosis is a neglected human disease caused by dimorphic Onygenales fungi. The disease is produced by the inflammatory response against growing adias...

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Autores principales:	Pedro Enrique Navas-Suárez, Carlos Sacristán, Josue Díaz-Delgado, Débora R. Yogui, Mario Henrique Alves, Danny Fuentes-Castillo, Catalina Ospina-Pinto, Roberta Ramblas Zamana, Arnaud Leonard Jean Desbiez, Jose Luiz Catão-Dias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72d8ca5aa7014eb29f2bf2e18e92a8d5
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spelling	oai:doaj.org-article:72d8ca5aa7014eb29f2bf2e18e92a8d52021-12-02T14:12:46ZPulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil10.1038/s41598-020-79521-62045-2322https://doaj.org/article/72d8ca5aa7014eb29f2bf2e18e92a8d52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79521-6https://doaj.org/toc/2045-2322Abstract Knowledge of infectious diseases in wildlife provides important information for preventing potential outbreaks of zoonotic diseases. Adiaspiromycosis is a neglected human disease caused by dimorphic Onygenales fungi. The disease is produced by the inflammatory response against growing adiaspores, leading to granulomatous pneumonia. In humans, adiaspiromycosis is relevant in immunosuppressed patients. In animals, it is associated with pneumonia in fossorial species. Given the potential role of armadillos in the epidemiology of adiaspiromycosis, in this study, we sought to investigate the occurrence and pathological features of adiaspiromycosis in roadkilled armadillos. In total, 54 armadillo carcasses were suitable for postmortem pathologic examinations between February 2017 and 2020. Adiaspores, associated with granulomatous lesions, were observed in ten six-banded (Euphractus sexcinctus) and two southern naked-tailed armadillos (Cabassous unicinctus). A previously uncharacterized Onygenales species was molecularly identified in two E. sexcinctus. In summary, herein we report 12 cases of pulmonary adiaspiromycosis (PA) in two species of free-living armadillos in Brazil. Both, the morphology of the fungus, as well as the histopathological findings (granulomatous inflammatory response to adiaspores) are consistent with PA; however, as the molecular identification differs from the reported species, the potential impact of this fungus for human PA is unknown, and we cannot rule out its impact on public health.Pedro Enrique Navas-SuárezCarlos SacristánJosue Díaz-DelgadoDébora R. YoguiMario Henrique AlvesDanny Fuentes-CastilloCatalina Ospina-PintoRoberta Ramblas ZamanaArnaud Leonard Jean DesbiezJose Luiz Catão-DiasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pedro Enrique Navas-Suárez Carlos Sacristán Josue Díaz-Delgado Débora R. Yogui Mario Henrique Alves Danny Fuentes-Castillo Catalina Ospina-Pinto Roberta Ramblas Zamana Arnaud Leonard Jean Desbiez Jose Luiz Catão-Dias Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil
description	Abstract Knowledge of infectious diseases in wildlife provides important information for preventing potential outbreaks of zoonotic diseases. Adiaspiromycosis is a neglected human disease caused by dimorphic Onygenales fungi. The disease is produced by the inflammatory response against growing adiaspores, leading to granulomatous pneumonia. In humans, adiaspiromycosis is relevant in immunosuppressed patients. In animals, it is associated with pneumonia in fossorial species. Given the potential role of armadillos in the epidemiology of adiaspiromycosis, in this study, we sought to investigate the occurrence and pathological features of adiaspiromycosis in roadkilled armadillos. In total, 54 armadillo carcasses were suitable for postmortem pathologic examinations between February 2017 and 2020. Adiaspores, associated with granulomatous lesions, were observed in ten six-banded (Euphractus sexcinctus) and two southern naked-tailed armadillos (Cabassous unicinctus). A previously uncharacterized Onygenales species was molecularly identified in two E. sexcinctus. In summary, herein we report 12 cases of pulmonary adiaspiromycosis (PA) in two species of free-living armadillos in Brazil. Both, the morphology of the fungus, as well as the histopathological findings (granulomatous inflammatory response to adiaspores) are consistent with PA; however, as the molecular identification differs from the reported species, the potential impact of this fungus for human PA is unknown, and we cannot rule out its impact on public health.
format	article
author	Pedro Enrique Navas-Suárez Carlos Sacristán Josue Díaz-Delgado Débora R. Yogui Mario Henrique Alves Danny Fuentes-Castillo Catalina Ospina-Pinto Roberta Ramblas Zamana Arnaud Leonard Jean Desbiez Jose Luiz Catão-Dias
author_facet	Pedro Enrique Navas-Suárez Carlos Sacristán Josue Díaz-Delgado Débora R. Yogui Mario Henrique Alves Danny Fuentes-Castillo Catalina Ospina-Pinto Roberta Ramblas Zamana Arnaud Leonard Jean Desbiez Jose Luiz Catão-Dias
author_sort	Pedro Enrique Navas-Suárez
title	Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil
title_short	Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil
title_full	Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil
title_fullStr	Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil
title_full_unstemmed	Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil
title_sort	pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in brazil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72d8ca5aa7014eb29f2bf2e18e92a8d5
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Pulmonary adiaspiromycosis in armadillos killed by motor vehicle collisions in Brazil

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