Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

Abstract Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a vir...

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Autores principales:	Anush Arakelyan, Wendy Fitzgerald, Sonia Zicari, Christophe Vanpouille, Leonid Margolis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72de3d4f33a14ec5b85b36987459cf7a
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spelling	oai:doaj.org-article:72de3d4f33a14ec5b85b36987459cf7a2021-12-02T11:53:14ZExtracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue10.1038/s41598-017-01739-82045-2322https://doaj.org/article/72de3d4f33a14ec5b85b36987459cf7a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01739-8https://doaj.org/toc/2045-2322Abstract Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy.Anush ArakelyanWendy FitzgeraldSonia ZicariChristophe VanpouilleLeonid MargolisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anush Arakelyan Wendy Fitzgerald Sonia Zicari Christophe Vanpouille Leonid Margolis Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
description	Abstract Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy.
format	article
author	Anush Arakelyan Wendy Fitzgerald Sonia Zicari Christophe Vanpouille Leonid Margolis
author_facet	Anush Arakelyan Wendy Fitzgerald Sonia Zicari Christophe Vanpouille Leonid Margolis
author_sort	Anush Arakelyan
title	Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_short	Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_full	Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_fullStr	Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_full_unstemmed	Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_sort	extracellular vesicles carry hiv env and facilitate hiv infection of human lymphoid tissue
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/72de3d4f33a14ec5b85b36987459cf7a
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_version_	1718394812621651968

Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

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