MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.

Systemic drug delivery to solid tumors involving macromolecular therapeutic agents is challenging for many reasons. Amongst them is their chaotic microvasculature which often leads to inadequate and uneven uptake of the drug. Localized drug delivery can circumvent such obstacles and convection-enhan...

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Autores principales:	Kulam Najmudeen Magdoom, Gregory L Pishko, Lori Rice, Chris Pampo, Dietmar W Siemann, Malisa Sarntinoranont
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72df9a7d4b0240559090cc0a411ee7ef
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spelling	oai:doaj.org-article:72df9a7d4b0240559090cc0a411ee7ef2021-11-18T08:28:36ZMRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.1932-620310.1371/journal.pone.0089594https://doaj.org/article/72df9a7d4b0240559090cc0a411ee7ef2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24619021/?tool=EBIhttps://doaj.org/toc/1932-6203Systemic drug delivery to solid tumors involving macromolecular therapeutic agents is challenging for many reasons. Amongst them is their chaotic microvasculature which often leads to inadequate and uneven uptake of the drug. Localized drug delivery can circumvent such obstacles and convection-enhanced delivery (CED)--controlled infusion of the drug directly into the tissue--has emerged as a promising delivery method for distributing macromolecules over larger tissue volumes. In this study, a three-dimensional MR image-based computational porous media transport model accounting for realistic anatomical geometry and tumor leakiness was developed for predicting the interstitial flow field and distribution of albumin tracer following CED into the hind-limb tumor (KHT sarcoma) in a mouse. Sensitivity of the model to changes in infusion flow rate, catheter placement and tissue hydraulic conductivity were investigated. The model predictions suggest that 1) tracer distribution is asymmetric due to heterogeneous porosity; 2) tracer distribution volume varies linearly with infusion volume within the whole leg, and exponentially within the tumor reaching a maximum steady-state value; 3) infusion at the center of the tumor with high flow rates leads to maximum tracer coverage in the tumor with minimal leakage outside; and 4) increasing the tissue hydraulic conductivity lowers the tumor interstitial fluid pressure and decreases the tracer distribution volume within the whole leg and tumor. The model thus predicts that the interstitial fluid flow and drug transport is sensitive to porosity and changes in extracellular space. This image-based model thus serves as a potential tool for exploring the effects of transport heterogeneity in tumors.Kulam Najmudeen MagdoomGregory L PishkoLori RiceChris PampoDietmar W SiemannMalisa SarntinoranontPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e89594 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kulam Najmudeen Magdoom Gregory L Pishko Lori Rice Chris Pampo Dietmar W Siemann Malisa Sarntinoranont MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.
description	Systemic drug delivery to solid tumors involving macromolecular therapeutic agents is challenging for many reasons. Amongst them is their chaotic microvasculature which often leads to inadequate and uneven uptake of the drug. Localized drug delivery can circumvent such obstacles and convection-enhanced delivery (CED)--controlled infusion of the drug directly into the tissue--has emerged as a promising delivery method for distributing macromolecules over larger tissue volumes. In this study, a three-dimensional MR image-based computational porous media transport model accounting for realistic anatomical geometry and tumor leakiness was developed for predicting the interstitial flow field and distribution of albumin tracer following CED into the hind-limb tumor (KHT sarcoma) in a mouse. Sensitivity of the model to changes in infusion flow rate, catheter placement and tissue hydraulic conductivity were investigated. The model predictions suggest that 1) tracer distribution is asymmetric due to heterogeneous porosity; 2) tracer distribution volume varies linearly with infusion volume within the whole leg, and exponentially within the tumor reaching a maximum steady-state value; 3) infusion at the center of the tumor with high flow rates leads to maximum tracer coverage in the tumor with minimal leakage outside; and 4) increasing the tissue hydraulic conductivity lowers the tumor interstitial fluid pressure and decreases the tracer distribution volume within the whole leg and tumor. The model thus predicts that the interstitial fluid flow and drug transport is sensitive to porosity and changes in extracellular space. This image-based model thus serves as a potential tool for exploring the effects of transport heterogeneity in tumors.
format	article
author	Kulam Najmudeen Magdoom Gregory L Pishko Lori Rice Chris Pampo Dietmar W Siemann Malisa Sarntinoranont
author_facet	Kulam Najmudeen Magdoom Gregory L Pishko Lori Rice Chris Pampo Dietmar W Siemann Malisa Sarntinoranont
author_sort	Kulam Najmudeen Magdoom
title	MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.
title_short	MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.
title_full	MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.
title_fullStr	MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.
title_full_unstemmed	MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.
title_sort	mri-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/72df9a7d4b0240559090cc0a411ee7ef
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MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor.

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