Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels

The application of biopolymers in tissue engineering is of a great interest due to of their inherent properties such as cell adhesion, biodegradation, bioavailability, and viscoelasticity. In this study, we synthesized cryogels based on biopolymers of gelatin, chitosan, and chondroitin sulfate by cr...

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Autores principales:	Gulshakhar Kudaibergen, Madina Zhunussova, Ellina A. Mun, Anar Arinova, Vyacheslav Ogay
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cryogels gelatin chitosan chondroitin sulfate biopolymers cells Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/72e530563e214601a3c86802a079c12b
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spelling	oai:doaj.org-article:72e530563e214601a3c86802a079c12b2021-11-11T15:07:41ZStudying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels10.3390/app1121100562076-3417https://doaj.org/article/72e530563e214601a3c86802a079c12b2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10056https://doaj.org/toc/2076-3417The application of biopolymers in tissue engineering is of a great interest due to of their inherent properties such as cell adhesion, biodegradation, bioavailability, and viscoelasticity. In this study, we synthesized cryogels based on biopolymers of gelatin, chitosan, and chondroitin sulfate by cryopolymerization and studied the effect of chondroitin sulfate on changing the physicochemical properties of cryogels such as pore size, pore volume, density, gel fraction, and biodegradation. A macroporous surface of the synthesized polymers has been investigated by SEM. The glass transition temperatures of the crosslinked cryogels, determined by the DSC method, were higher compared to that of the non-crosslinked cryogel used as a reference. The results of the MTT test showed that aqueous extracts of the prepared cryogels had no toxic effect on rat adipose-derived mesenchymal stem cells. The research in this area is of great importance and provides new insights into novel, effective methods for obtaining biopolymers that can be used as carriers of cells.Gulshakhar KudaibergenMadina ZhunussovaEllina A. MunAnar ArinovaVyacheslav OgayMDPI AGarticlecryogelsgelatinchitosanchondroitin sulfatebiopolymerscellsTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10056, p 10056 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cryogels gelatin chitosan chondroitin sulfate biopolymers cells Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	cryogels gelatin chitosan chondroitin sulfate biopolymers cells Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Gulshakhar Kudaibergen Madina Zhunussova Ellina A. Mun Anar Arinova Vyacheslav Ogay Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels
description	The application of biopolymers in tissue engineering is of a great interest due to of their inherent properties such as cell adhesion, biodegradation, bioavailability, and viscoelasticity. In this study, we synthesized cryogels based on biopolymers of gelatin, chitosan, and chondroitin sulfate by cryopolymerization and studied the effect of chondroitin sulfate on changing the physicochemical properties of cryogels such as pore size, pore volume, density, gel fraction, and biodegradation. A macroporous surface of the synthesized polymers has been investigated by SEM. The glass transition temperatures of the crosslinked cryogels, determined by the DSC method, were higher compared to that of the non-crosslinked cryogel used as a reference. The results of the MTT test showed that aqueous extracts of the prepared cryogels had no toxic effect on rat adipose-derived mesenchymal stem cells. The research in this area is of great importance and provides new insights into novel, effective methods for obtaining biopolymers that can be used as carriers of cells.
format	article
author	Gulshakhar Kudaibergen Madina Zhunussova Ellina A. Mun Anar Arinova Vyacheslav Ogay
author_facet	Gulshakhar Kudaibergen Madina Zhunussova Ellina A. Mun Anar Arinova Vyacheslav Ogay
author_sort	Gulshakhar Kudaibergen
title	Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels
title_short	Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels
title_full	Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels
title_fullStr	Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels
title_full_unstemmed	Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels
title_sort	studying the effect of chondroitin sulfate on the physicochemical properties of novel gelatin/chitosan biopolymer-based cryogels
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72e530563e214601a3c86802a079c12b
work_keys_str_mv	AT gulshakharkudaibergen studyingtheeffectofchondroitinsulfateonthephysicochemicalpropertiesofnovelgelatinchitosanbiopolymerbasedcryogels AT madinazhunussova studyingtheeffectofchondroitinsulfateonthephysicochemicalpropertiesofnovelgelatinchitosanbiopolymerbasedcryogels AT ellinaamun studyingtheeffectofchondroitinsulfateonthephysicochemicalpropertiesofnovelgelatinchitosanbiopolymerbasedcryogels AT anararinova studyingtheeffectofchondroitinsulfateonthephysicochemicalpropertiesofnovelgelatinchitosanbiopolymerbasedcryogels AT vyacheslavogay studyingtheeffectofchondroitinsulfateonthephysicochemicalpropertiesofnovelgelatinchitosanbiopolymerbasedcryogels
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Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels

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