<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles

The metabolites profile of a plant is greatly influenced by geographical factors and the ecological environment. Various studies focused on artemisinin and its derivates for their antiparasitic and antitumoral effects. However, after the isolation and purification stage, their pharmaceutical potenti...

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Autores principales:	Adina-Elena Segneanu, Catalin Nicolae Marin, Ioan Ovidiu-Florin Ghirlea, Catalin Vladut Ionut Feier, Cornelia Muntean, Ioan Grozescu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	secondary metabolites GC-MS mass-spectra bioactive compounds nano-carrier system magnetic nanoparticles Botany QK1-989
Acceso en línea:	https://doaj.org/article/72e592b7a458412c95a2442460ac7b90
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spelling	oai:doaj.org-article:72e592b7a458412c95a2442460ac7b902021-11-25T18:44:09Z<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles10.3390/plants101122452223-7747https://doaj.org/article/72e592b7a458412c95a2442460ac7b902021-10-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2245https://doaj.org/toc/2223-7747The metabolites profile of a plant is greatly influenced by geographical factors and the ecological environment. Various studies focused on artemisinin and its derivates for their antiparasitic and antitumoral effects. However, after the isolation and purification stage, their pharmaceutical potential is limited due to their low bioavailability, permeability and lifetime. The antibacterial activity of essential oils has been another topic of interest for many studies on this plant. Nevertheless, only a few studies investigate other metabolites in <i>Artemisia annua</i>. Considering that secondary metabolites act synergistically in a plant, the existence of other metabolites with antitumor and high immunomodulating activity is even more important. Novel nano-carrier systems obtained by loading herbs into magnetic nanoparticles ensures the increase in the antitumor effect, but also, overcoming the barriers related to permeability, localization. This study reported the first complete metabolic profile from wild grown Romanian <i>Artemisia annua</i>. A total of 103 metabolites were identified under mass spectra (MS) positive mode from 13 secondary metabolite categories: amino acids, terpenoids, steroids, coumarins, flavonoids, organic acids, fatty acids, phenolic acids, carbohydrates, glycosides, aldehydes, hydrocarbons, etc. In addition, the biological activity of each class of metabolites was discussed. We further developed a simple and inexpensive nano-carrier system with the intention to capitalize on the beneficial properties of both components. Evaluation of the nano-carrier system’s morpho-structural and magnetic properties was performed.Adina-Elena SegneanuCatalin Nicolae MarinIoan Ovidiu-Florin GhirleaCatalin Vladut Ionut FeierCornelia MunteanIoan GrozescuMDPI AGarticlesecondary metabolitesGC-MSmass-spectrabioactive compoundsnano-carrier systemmagnetic nanoparticlesBotanyQK1-989ENPlants, Vol 10, Iss 2245, p 2245 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	secondary metabolites GC-MS mass-spectra bioactive compounds nano-carrier system magnetic nanoparticles Botany QK1-989
spellingShingle	secondary metabolites GC-MS mass-spectra bioactive compounds nano-carrier system magnetic nanoparticles Botany QK1-989 Adina-Elena Segneanu Catalin Nicolae Marin Ioan Ovidiu-Florin Ghirlea Catalin Vladut Ionut Feier Cornelia Muntean Ioan Grozescu <i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles
description	The metabolites profile of a plant is greatly influenced by geographical factors and the ecological environment. Various studies focused on artemisinin and its derivates for their antiparasitic and antitumoral effects. However, after the isolation and purification stage, their pharmaceutical potential is limited due to their low bioavailability, permeability and lifetime. The antibacterial activity of essential oils has been another topic of interest for many studies on this plant. Nevertheless, only a few studies investigate other metabolites in <i>Artemisia annua</i>. Considering that secondary metabolites act synergistically in a plant, the existence of other metabolites with antitumor and high immunomodulating activity is even more important. Novel nano-carrier systems obtained by loading herbs into magnetic nanoparticles ensures the increase in the antitumor effect, but also, overcoming the barriers related to permeability, localization. This study reported the first complete metabolic profile from wild grown Romanian <i>Artemisia annua</i>. A total of 103 metabolites were identified under mass spectra (MS) positive mode from 13 secondary metabolite categories: amino acids, terpenoids, steroids, coumarins, flavonoids, organic acids, fatty acids, phenolic acids, carbohydrates, glycosides, aldehydes, hydrocarbons, etc. In addition, the biological activity of each class of metabolites was discussed. We further developed a simple and inexpensive nano-carrier system with the intention to capitalize on the beneficial properties of both components. Evaluation of the nano-carrier system’s morpho-structural and magnetic properties was performed.
format	article
author	Adina-Elena Segneanu Catalin Nicolae Marin Ioan Ovidiu-Florin Ghirlea Catalin Vladut Ionut Feier Cornelia Muntean Ioan Grozescu
author_facet	Adina-Elena Segneanu Catalin Nicolae Marin Ioan Ovidiu-Florin Ghirlea Catalin Vladut Ionut Feier Cornelia Muntean Ioan Grozescu
author_sort	Adina-Elena Segneanu
title	<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles
title_short	<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles
title_full	<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles
title_fullStr	<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles
title_full_unstemmed	<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles
title_sort	<i>artemisia annua</i> growing wild in romania—a metabolite profile approach to target a drug delivery system based on magnetite nanoparticles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72e592b7a458412c95a2442460ac7b90
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<i>Artemisia annua</i> Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles

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