Influence of acute complications on outcome 3 months after ischemic stroke.

<h4>Background</h4>Early medical complications are potentially modifiable factors influencing in-hospital outcome. We investigated the influence of acute complications on mortality and poor outcome 3 months after ischemic stroke.<h4>Methods</h4>Data were obtained from patient...

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Autores principales:	Maike Miriam Grube, Hans-Christian Koennecke, Georg Walter, Andreas Meisel, Jan Sobesky, Christian Hans Nolte, Ian Wellwood, Peter Ulrich Heuschmann, Berlin Stroke Register (BSR)
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72e7da015f584d6b9be7f8cf06703f73
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spelling	oai:doaj.org-article:72e7da015f584d6b9be7f8cf06703f732021-11-18T08:53:58ZInfluence of acute complications on outcome 3 months after ischemic stroke.1932-620310.1371/journal.pone.0075719https://doaj.org/article/72e7da015f584d6b9be7f8cf06703f732013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086621/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Early medical complications are potentially modifiable factors influencing in-hospital outcome. We investigated the influence of acute complications on mortality and poor outcome 3 months after ischemic stroke.<h4>Methods</h4>Data were obtained from patients admitted to one of 13 stroke units of the Berlin Stroke Registry (BSR) who participated in a 3-months-follow up between June 2010 and September 2012. We examined the influence of the cumulative number of early in-hospital complications on mortality and poor outcome (death, disability or institutionalization) 3 months after stroke using multivariable logistic regression analyses and calculated attributable fractions to determine the impact of early complications on mortality and poor outcome.<h4>Results</h4>A total of 2349 ischemic stroke patients alive at discharge from acute care were included in the analysis. Older age, stroke severity, pre-stroke dependency and early complications were independent predictors of mortality 3 months after stroke. Poor outcome was independently associated with older age, stroke severity, pre-stroke dependency, previous stroke and early complications. More than 60% of deaths and poor outcomes were attributed to age, pre-stroke dependency and stroke severity and in-hospital complications contributed to 12.3% of deaths and 9.1% of poor outcomes 3 months after stroke.<h4>Conclusion</h4>The majority of deaths and poor outcomes after stroke were attributed to non-modifiable factors. However, early in-hospital complications significantly affect outcome in patients who survived the acute phase after stroke, underlining the need to improve prevention and treatment of complications in hospital.Maike Miriam GrubeHans-Christian KoenneckeGeorg WalterAndreas MeiselJan SobeskyChristian Hans NolteIan WellwoodPeter Ulrich HeuschmannBerlin Stroke Register (BSR)Public Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75719 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maike Miriam Grube Hans-Christian Koennecke Georg Walter Andreas Meisel Jan Sobesky Christian Hans Nolte Ian Wellwood Peter Ulrich Heuschmann Berlin Stroke Register (BSR) Influence of acute complications on outcome 3 months after ischemic stroke.
description	<h4>Background</h4>Early medical complications are potentially modifiable factors influencing in-hospital outcome. We investigated the influence of acute complications on mortality and poor outcome 3 months after ischemic stroke.<h4>Methods</h4>Data were obtained from patients admitted to one of 13 stroke units of the Berlin Stroke Registry (BSR) who participated in a 3-months-follow up between June 2010 and September 2012. We examined the influence of the cumulative number of early in-hospital complications on mortality and poor outcome (death, disability or institutionalization) 3 months after stroke using multivariable logistic regression analyses and calculated attributable fractions to determine the impact of early complications on mortality and poor outcome.<h4>Results</h4>A total of 2349 ischemic stroke patients alive at discharge from acute care were included in the analysis. Older age, stroke severity, pre-stroke dependency and early complications were independent predictors of mortality 3 months after stroke. Poor outcome was independently associated with older age, stroke severity, pre-stroke dependency, previous stroke and early complications. More than 60% of deaths and poor outcomes were attributed to age, pre-stroke dependency and stroke severity and in-hospital complications contributed to 12.3% of deaths and 9.1% of poor outcomes 3 months after stroke.<h4>Conclusion</h4>The majority of deaths and poor outcomes after stroke were attributed to non-modifiable factors. However, early in-hospital complications significantly affect outcome in patients who survived the acute phase after stroke, underlining the need to improve prevention and treatment of complications in hospital.
format	article
author	Maike Miriam Grube Hans-Christian Koennecke Georg Walter Andreas Meisel Jan Sobesky Christian Hans Nolte Ian Wellwood Peter Ulrich Heuschmann Berlin Stroke Register (BSR)
author_facet	Maike Miriam Grube Hans-Christian Koennecke Georg Walter Andreas Meisel Jan Sobesky Christian Hans Nolte Ian Wellwood Peter Ulrich Heuschmann Berlin Stroke Register (BSR)
author_sort	Maike Miriam Grube
title	Influence of acute complications on outcome 3 months after ischemic stroke.
title_short	Influence of acute complications on outcome 3 months after ischemic stroke.
title_full	Influence of acute complications on outcome 3 months after ischemic stroke.
title_fullStr	Influence of acute complications on outcome 3 months after ischemic stroke.
title_full_unstemmed	Influence of acute complications on outcome 3 months after ischemic stroke.
title_sort	influence of acute complications on outcome 3 months after ischemic stroke.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/72e7da015f584d6b9be7f8cf06703f73
work_keys_str_mv	AT maikemiriamgrube influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT hanschristiankoennecke influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT georgwalter influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT andreasmeisel influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT jansobesky influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT christianhansnolte influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT ianwellwood influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT peterulrichheuschmann influenceofacutecomplicationsonoutcome3monthsafterischemicstroke AT berlinstrokeregisterbsr influenceofacutecomplicationsonoutcome3monthsafterischemicstroke
_version_	1718421208588877824

Influence of acute complications on outcome 3 months after ischemic stroke.

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