Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City

Yong Zhang,1,* Yuehua Yang,2,* Qian Zhang,3,* Jing Cui,4 Abdul Rahaman,5 Xiao-Rong Huang,6,7 Ya Su,4 Ruqin Gao,4 Bingling Wang,4 Zulqarnain Baloch6 1Department of Paediatric Surgery, Qingdao Women and Children’s Hospital, Qingdao, People’s Republic of China; 2Department of Obstet...

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Autores principales:	Zhang Y, Yang Y, Zhang Q, Cui J, Rahaman A, Huang XR, Su Y, Gao R, Wang B, Baloch Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	neurodevelopment pah-dna adducts;infant polycyclic aromatic hydrocarbons china Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/72eee03fe17b48a8a0e1cb36c0644ea0
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spelling	oai:doaj.org-article:72eee03fe17b48a8a0e1cb36c0644ea02021-12-02T04:11:23ZEffect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City1178-2021https://doaj.org/article/72eee03fe17b48a8a0e1cb36c0644ea02019-12-01T00:00:00Zhttps://www.dovepress.com/effect-of-benzoapyrene-dna-adduct-in-cord-blood-on-the-neurodevelopmen-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yong Zhang,1,* Yuehua Yang,2,* Qian Zhang,3,* Jing Cui,4 Abdul Rahaman,5 Xiao-Rong Huang,6,7 Ya Su,4 Ruqin Gao,4 Bingling Wang,4 Zulqarnain Baloch6 1Department of Paediatric Surgery, Qingdao Women and Children’s Hospital, Qingdao, People’s Republic of China; 2Department of Obstetrics, The Affiliated Central Hospital of Qingdao University, Qingdao, People’s Republic of China; 3Department of Child Health Care, Huangdao Maternity and Child Health Care Hospital of Qingdao, Qingdao, People’s Republic of China; 4Department of Environmental Health, Qingdao Centers for Disease Control and Prevention/Qingdao Institute for Preventive Medicine, Qingdao, People’s Republic of China; 5School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, People’s Republic of China; 6Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, People’s Republic of China; 7College of Veterinary Medicine, South China Agricultural University, Guangzhou, 51062, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zulqarnain BalochBiomedical Research Center, Northwest Minzu University, Lanzhou 730030, People’s Republic of ChinaTel/Fax +8618344564625Email znbalooch@yahoo.comBingling WangDepartment of Environmental Health, Qingdao Institute for Preventive Medicine, No. 175 Shandong Road, Qingdao 266033, People’s Republic of ChinaTel +86 532 85621975Fax +86 532 85623909Email binglingw@yeah.netIntroduction: The study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immunoassay.Methods: Child neurodevelopment was assessed at both 6 months and 12 months of age using the Gesell Development Inventory (GDI).Results: This study results reveal that multivariate linear analysis, cord BaP-DNA adduct level was inversely associated with developmental quotient score in the adaptive domain [β = −0.08; 95% CI: (−0.16, −0.003); p = 0.04], gross motor domain [β = −0.10; 95% CI: (−0.20, −0.01); p = 0.02], fine motor domain [β = −0.15; 95% CI: (−0.25, −0.05); p = 0.01], language domain [β = −0.12; 95% CI: (−0.21, −0.03); p = 0.02], and personal–social domain [β = −0.13; 95% CI: (−0.22, −0.04); p<0.01]. Further, multivariate logistic regression analysis showed increased cord BaP-DNA adduct levels associated with increased odds of delayed in language domain.Conclusion: In conclusion, the study suggested that prenatal PAH exposure monitored by umbilical cord blood BaP-DNA adducts may adversely affect the neurodevelopment of the infants at 12 months of age.Keywords: neurodevelopment, PAH-DNA adducts, infant, polycyclic aromatic hydrocarbons, ChinaZhang YYang YZhang QCui JRahaman AHuang XRSu YGao RWang BBaloch ZDove Medical Pressarticleneurodevelopmentpah-dna adducts;infantpolycyclic aromatic hydrocarbonschinaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3351-3357 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurodevelopment pah-dna adducts;infant polycyclic aromatic hydrocarbons china Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	neurodevelopment pah-dna adducts;infant polycyclic aromatic hydrocarbons china Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhang Y Yang Y Zhang Q Cui J Rahaman A Huang XR Su Y Gao R Wang B Baloch Z Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
description	Yong Zhang,1,* Yuehua Yang,2,* Qian Zhang,3,* Jing Cui,4 Abdul Rahaman,5 Xiao-Rong Huang,6,7 Ya Su,4 Ruqin Gao,4 Bingling Wang,4 Zulqarnain Baloch6 1Department of Paediatric Surgery, Qingdao Women and Children’s Hospital, Qingdao, People’s Republic of China; 2Department of Obstetrics, The Affiliated Central Hospital of Qingdao University, Qingdao, People’s Republic of China; 3Department of Child Health Care, Huangdao Maternity and Child Health Care Hospital of Qingdao, Qingdao, People’s Republic of China; 4Department of Environmental Health, Qingdao Centers for Disease Control and Prevention/Qingdao Institute for Preventive Medicine, Qingdao, People’s Republic of China; 5School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, People’s Republic of China; 6Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, People’s Republic of China; 7College of Veterinary Medicine, South China Agricultural University, Guangzhou, 51062, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zulqarnain BalochBiomedical Research Center, Northwest Minzu University, Lanzhou 730030, People’s Republic of ChinaTel/Fax +8618344564625Email znbalooch@yahoo.comBingling WangDepartment of Environmental Health, Qingdao Institute for Preventive Medicine, No. 175 Shandong Road, Qingdao 266033, People’s Republic of ChinaTel +86 532 85621975Fax +86 532 85623909Email binglingw@yeah.netIntroduction: The study was designed to explore the possible adverse effects of prenatal polycyclic aromatic hydrocarbons (PAHs) on the neurodevelopment of the infants at the age of 12 months in a birth cohort in Qingdao of China. Benzo[a]pyrene (BaP)-DNA adduct level in umbilical cord blood was measured by enzyme immunoassay.Methods: Child neurodevelopment was assessed at both 6 months and 12 months of age using the Gesell Development Inventory (GDI).Results: This study results reveal that multivariate linear analysis, cord BaP-DNA adduct level was inversely associated with developmental quotient score in the adaptive domain [β = −0.08; 95% CI: (−0.16, −0.003); p = 0.04], gross motor domain [β = −0.10; 95% CI: (−0.20, −0.01); p = 0.02], fine motor domain [β = −0.15; 95% CI: (−0.25, −0.05); p = 0.01], language domain [β = −0.12; 95% CI: (−0.21, −0.03); p = 0.02], and personal–social domain [β = −0.13; 95% CI: (−0.22, −0.04); p<0.01]. Further, multivariate logistic regression analysis showed increased cord BaP-DNA adduct levels associated with increased odds of delayed in language domain.Conclusion: In conclusion, the study suggested that prenatal PAH exposure monitored by umbilical cord blood BaP-DNA adducts may adversely affect the neurodevelopment of the infants at 12 months of age.Keywords: neurodevelopment, PAH-DNA adducts, infant, polycyclic aromatic hydrocarbons, China
format	article
author	Zhang Y Yang Y Zhang Q Cui J Rahaman A Huang XR Su Y Gao R Wang B Baloch Z
author_facet	Zhang Y Yang Y Zhang Q Cui J Rahaman A Huang XR Su Y Gao R Wang B Baloch Z
author_sort	Zhang Y
title	Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
title_short	Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
title_full	Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
title_fullStr	Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
title_full_unstemmed	Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City
title_sort	effect of benzo[a]pyrene-dna adduct in cord blood on the neurodevelopment of 12-month-old infants in qingdao city
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/72eee03fe17b48a8a0e1cb36c0644ea0
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Effect of Benzo[a]pyrene-DNA Adduct in Cord Blood on the Neurodevelopment of 12-Month-Old Infants in Qingdao City

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