The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers

Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammat...

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Autores principales:	Yoko Minokawa, Yu Sawada, Motonobu Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	omega-3 PUFA melanoma basal cell carcinoma lymphoma squamous cell carcinoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/72f82d5c2f3440fcb85a5d8834be9610
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id	oai:doaj.org-article:72f82d5c2f3440fcb85a5d8834be9610
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spelling	oai:doaj.org-article:72f82d5c2f3440fcb85a5d8834be96102021-11-25T17:22:03ZThe Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers10.3390/diagnostics111121492075-4418https://doaj.org/article/72f82d5c2f3440fcb85a5d8834be96102021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2149https://doaj.org/toc/2075-4418Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammatory diseases. In addition to their therapeutic potency against inflammation, omega-3 PUFAs have also been shown to have anti-tumor effects via various mechanisms, such as cell arrest and apoptosis. To date, limited information is available on these effects in cutaneous malignancies. In this review, we focused on the effect of omega-3 PUFAs on skin cancers, especially malignant melanoma, basal cell carcinoma, lymphoma, and squamous cell carcinoma and discussed the detailed molecular mechanism of the omega-3 PUFA-mediated anti-tumor response. We also explored the molecular mechanisms mediated by epigenetic modifications, cell adhesion molecules, and anti-tumor immune responses.Yoko MinokawaYu SawadaMotonobu NakamuraMDPI AGarticleomega-3 PUFAmelanomabasal cell carcinomalymphomasquamous cell carcinomaMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2149, p 2149 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	omega-3 PUFA melanoma basal cell carcinoma lymphoma squamous cell carcinoma Medicine (General) R5-920
spellingShingle	omega-3 PUFA melanoma basal cell carcinoma lymphoma squamous cell carcinoma Medicine (General) R5-920 Yoko Minokawa Yu Sawada Motonobu Nakamura The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
description	Dietary nutrition intake is essential for human beings and influences various physiological and pathological actions in the human body. Among various nutritional factors, dietary intake of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to have various beneficial effects against inflammatory diseases. In addition to their therapeutic potency against inflammation, omega-3 PUFAs have also been shown to have anti-tumor effects via various mechanisms, such as cell arrest and apoptosis. To date, limited information is available on these effects in cutaneous malignancies. In this review, we focused on the effect of omega-3 PUFAs on skin cancers, especially malignant melanoma, basal cell carcinoma, lymphoma, and squamous cell carcinoma and discussed the detailed molecular mechanism of the omega-3 PUFA-mediated anti-tumor response. We also explored the molecular mechanisms mediated by epigenetic modifications, cell adhesion molecules, and anti-tumor immune responses.
format	article
author	Yoko Minokawa Yu Sawada Motonobu Nakamura
author_facet	Yoko Minokawa Yu Sawada Motonobu Nakamura
author_sort	Yoko Minokawa
title	The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_short	The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_full	The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_fullStr	The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_full_unstemmed	The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers
title_sort	influences of omega-3 polyunsaturated fatty acids on the development of skin cancers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72f82d5c2f3440fcb85a5d8834be9610
work_keys_str_mv	AT yokominokawa theinfluencesofomega3polyunsaturatedfattyacidsonthedevelopmentofskincancers AT yusawada theinfluencesofomega3polyunsaturatedfattyacidsonthedevelopmentofskincancers AT motonobunakamura theinfluencesofomega3polyunsaturatedfattyacidsonthedevelopmentofskincancers AT yokominokawa influencesofomega3polyunsaturatedfattyacidsonthedevelopmentofskincancers AT yusawada influencesofomega3polyunsaturatedfattyacidsonthedevelopmentofskincancers AT motonobunakamura influencesofomega3polyunsaturatedfattyacidsonthedevelopmentofskincancers
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The Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers

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