VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium

Abstract Ischemic heart disease (IHD) and dilated cardiomyopathy (DCM) are the two most common etiologies of heart failure (HF). Both forms share common characteristics including ventricle dilation in the final stage. Immune mechanisms in HF are increasingly highlighted and have been implicated in t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tongyu Wang, Jiahu Tian, Yuanzhe Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/72f853f49f714da49f1d3784292cbaf1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:72f853f49f714da49f1d3784292cbaf1
record_format	dspace
spelling	oai:doaj.org-article:72f853f49f714da49f1d3784292cbaf12021-12-02T17:17:40ZVCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium10.1038/s41598-021-98998-32045-2322https://doaj.org/article/72f853f49f714da49f1d3784292cbaf12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98998-3https://doaj.org/toc/2045-2322Abstract Ischemic heart disease (IHD) and dilated cardiomyopathy (DCM) are the two most common etiologies of heart failure (HF). Both forms share common characteristics including ventricle dilation in the final stage. Immune mechanisms in HF are increasingly highlighted and have been implicated in the pathogeneses of IHD and DCM. A better understanding of adhesion molecule expression and correlated immune cell infiltration could enhance disease detection and improve therapeutic targets. This study was performed to explore the common mechanisms underlying IHD and DCM. After searching the Gene Expression Omnibus database, we selected the GSE42955, GSE76701, GSE5406, GSE133054 and GSE57338 datasets for different expressed gene (DEGs) selection and new cohort establishment. We use xcell to calculate immune infiltration degree, ssGSEA and GSEA to calculate the pathway and biological enrichment score, consensus cluster to identify the m6A modification pattern, and LASSO regression to make risk predicting model and use new combined cohort to validate the results. The screening stage revealed that vascular cell adhesion molecule 1 (VCAM1) play pivotal roles in regulating DEGs. Subsequent analyses revealed that VCAM1 was differentially expressed in the myocardium and involved in regulating immune cell infiltration. We also found that dysregulated VCAM1 expression was associated with a higher risk of HF by constructing a clinical risk-predicting model. Besides, we also find a connection among the m6A RNA modification ,expression of VCAM1 and immune regulation. Those connection can be linked by the Wnt pathway enrichment alternation. Collectively, our results suggest that VCAM-1 have the potential to be used as a biomarker or therapy target for HF and the m6A modification pattern is associated with the VCAM1 expression and immune regulation.Tongyu WangJiahu TianYuanzhe JinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tongyu Wang Jiahu Tian Yuanzhe Jin VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium
description	Abstract Ischemic heart disease (IHD) and dilated cardiomyopathy (DCM) are the two most common etiologies of heart failure (HF). Both forms share common characteristics including ventricle dilation in the final stage. Immune mechanisms in HF are increasingly highlighted and have been implicated in the pathogeneses of IHD and DCM. A better understanding of adhesion molecule expression and correlated immune cell infiltration could enhance disease detection and improve therapeutic targets. This study was performed to explore the common mechanisms underlying IHD and DCM. After searching the Gene Expression Omnibus database, we selected the GSE42955, GSE76701, GSE5406, GSE133054 and GSE57338 datasets for different expressed gene (DEGs) selection and new cohort establishment. We use xcell to calculate immune infiltration degree, ssGSEA and GSEA to calculate the pathway and biological enrichment score, consensus cluster to identify the m6A modification pattern, and LASSO regression to make risk predicting model and use new combined cohort to validate the results. The screening stage revealed that vascular cell adhesion molecule 1 (VCAM1) play pivotal roles in regulating DEGs. Subsequent analyses revealed that VCAM1 was differentially expressed in the myocardium and involved in regulating immune cell infiltration. We also found that dysregulated VCAM1 expression was associated with a higher risk of HF by constructing a clinical risk-predicting model. Besides, we also find a connection among the m6A RNA modification ,expression of VCAM1 and immune regulation. Those connection can be linked by the Wnt pathway enrichment alternation. Collectively, our results suggest that VCAM-1 have the potential to be used as a biomarker or therapy target for HF and the m6A modification pattern is associated with the VCAM1 expression and immune regulation.
format	article
author	Tongyu Wang Jiahu Tian Yuanzhe Jin
author_facet	Tongyu Wang Jiahu Tian Yuanzhe Jin
author_sort	Tongyu Wang
title	VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium
title_short	VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium
title_full	VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium
title_fullStr	VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium
title_full_unstemmed	VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium
title_sort	vcam1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/72f853f49f714da49f1d3784292cbaf1
work_keys_str_mv	AT tongyuwang vcam1expressioninthemyocardiumisassociatedwiththeriskofheartfailureandimmunecellinfiltrationinmyocardium AT jiahutian vcam1expressioninthemyocardiumisassociatedwiththeriskofheartfailureandimmunecellinfiltrationinmyocardium AT yuanzhejin vcam1expressioninthemyocardiumisassociatedwiththeriskofheartfailureandimmunecellinfiltrationinmyocardium
_version_	1718381150793105408

VCAM1 expression in the myocardium is associated with the risk of heart failure and immune cell infiltration in myocardium

Ejemplares similares