Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy

Background. Italy was the first western country to face an uncontrolled outbreak of SARS-CoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes...

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Autores principales:	Marina Sartini, Filippo Del Puente, Martino Oliva, Alessio Carbone, Elisabetta Blasi Vacca, Andrea Parisini, Silvia Boni, Nicoletta Bobbio, Marcello Feasi, Alessandra Battistella, Emanuele Pontali, Maria Luisa Cristina
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 outcome clinical trends Medicine R
Acceso en línea:	https://doaj.org/article/72fabe4c5c894fa9a374086e080ab9ee
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spelling	oai:doaj.org-article:72fabe4c5c894fa9a374086e080ab9ee2021-11-25T18:00:47ZRiding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy10.3390/jcm102252392077-0383https://doaj.org/article/72fabe4c5c894fa9a374086e080ab9ee2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5239https://doaj.org/toc/2077-0383Background. Italy was the first western country to face an uncontrolled outbreak of SARS-CoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes. The aim of our study was to evaluate the effects of these changes. Methods. Data from a hospital in Genoa, Italy, were analysed. Patients deceased from SARS-CoV-2 infection were selected. Data were compared by dividing patients into two cohorts: “phase A” (March–May 2020) and “phase B” (October–December 2020). Results. A total of 5142 patients were admitted. There were 274 SARS-CoV-2-related deaths (162 phase A and 112 phase B). No differences were observed in terms of demographics, presentation, or comorbidities. A significant increase was recorded in corticosteroid use. Mortality was 33.36% during phase A, falling to 21.71% during phase B. When subdividing the trend during the two phases by age, we found a difference in people aged 65–74 years. Conclusions. There is scarce evidence regarding treatment for SARS-CoV-2 (especially for severe infection). However, treatment changes improved the prognosis for people under the age of 75. The prognosis for older people remains poor, despite the improvements achieved.Marina SartiniFilippo Del PuenteMartino OlivaAlessio CarboneElisabetta Blasi VaccaAndrea ParisiniSilvia BoniNicoletta BobbioMarcello FeasiAlessandra BattistellaEmanuele PontaliMaria Luisa CristinaMDPI AGarticleSARS-CoV-2outcomeclinical trendsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5239, p 5239 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 outcome clinical trends Medicine R
spellingShingle	SARS-CoV-2 outcome clinical trends Medicine R Marina Sartini Filippo Del Puente Martino Oliva Alessio Carbone Elisabetta Blasi Vacca Andrea Parisini Silvia Boni Nicoletta Bobbio Marcello Feasi Alessandra Battistella Emanuele Pontali Maria Luisa Cristina Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
description	Background. Italy was the first western country to face an uncontrolled outbreak of SARS-CoV-2 infection. The epidemic began in March 2020 within a context characterised by a general lack of knowledge about the disease. The first scientific evidence emerged months later, leading to treatment changes. The aim of our study was to evaluate the effects of these changes. Methods. Data from a hospital in Genoa, Italy, were analysed. Patients deceased from SARS-CoV-2 infection were selected. Data were compared by dividing patients into two cohorts: “phase A” (March–May 2020) and “phase B” (October–December 2020). Results. A total of 5142 patients were admitted. There were 274 SARS-CoV-2-related deaths (162 phase A and 112 phase B). No differences were observed in terms of demographics, presentation, or comorbidities. A significant increase was recorded in corticosteroid use. Mortality was 33.36% during phase A, falling to 21.71% during phase B. When subdividing the trend during the two phases by age, we found a difference in people aged 65–74 years. Conclusions. There is scarce evidence regarding treatment for SARS-CoV-2 (especially for severe infection). However, treatment changes improved the prognosis for people under the age of 75. The prognosis for older people remains poor, despite the improvements achieved.
format	article
author	Marina Sartini Filippo Del Puente Martino Oliva Alessio Carbone Elisabetta Blasi Vacca Andrea Parisini Silvia Boni Nicoletta Bobbio Marcello Feasi Alessandra Battistella Emanuele Pontali Maria Luisa Cristina
author_facet	Marina Sartini Filippo Del Puente Martino Oliva Alessio Carbone Elisabetta Blasi Vacca Andrea Parisini Silvia Boni Nicoletta Bobbio Marcello Feasi Alessandra Battistella Emanuele Pontali Maria Luisa Cristina
author_sort	Marina Sartini
title	Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_short	Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_full	Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_fullStr	Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_full_unstemmed	Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy
title_sort	riding the covid waves: clinical trends, outcomes, and remaining pitfalls of the sars-cov-2 pandemic: an analysis of two high-incidence periods at a hospital in northern italy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/72fabe4c5c894fa9a374086e080ab9ee
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Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy

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