New onset diabetes after transplantation (NODAT): an overview

Phuong-Thu T Pham1, Phuong-Mai T Pham2,3, Son V Pham4, Phuong-Anh T Pham5, Phuong-Chi T Pham2,61Nephrology Division, Kidney Transplant Program, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2David Geffen School of Medicine at UCLA, Los Angeles, CA; 3Department of...

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Autores principales:	Pham PT, Pham PM, Pham SV, Pham PA, Pham PC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/72fe5862bc054eaf813ad65e9b0db2b7
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spelling	oai:doaj.org-article:72fe5862bc054eaf813ad65e9b0db2b72021-12-02T04:00:34ZNew onset diabetes after transplantation (NODAT): an overview1178-7007https://doaj.org/article/72fe5862bc054eaf813ad65e9b0db2b72011-05-01T00:00:00Zhttp://www.dovepress.com/new-onset-diabetes-after-transplantation-nodat-an-overview-a7383https://doaj.org/toc/1178-7007Phuong-Thu T Pham1, Phuong-Mai T Pham2,3, Son V Pham4, Phuong-Anh T Pham5, Phuong-Chi T Pham2,61Nephrology Division, Kidney Transplant Program, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2David Geffen School of Medicine at UCLA, Los Angeles, CA; 3Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA; 4Division of Cardiology, Bay Pines VA Medical Center, Bay Pines, FL; 5Division of Cardiology, Memphis VA Medical Center, Memphis, TN; 6Department of Medicine, Nephrology Division, UCLA Olive View Medical Center, Los Angeles, CA, USAAbstract: Although renal transplantation ameliorates cardiovascular risk factors by restoring renal function, it introduces new cardiovascular risks including impaired glucose tolerance or diabetes mellitus, hypertension, and dyslipidemia that are derived, in part, from immunosuppressive medications such as calcineurin inhibitors, corticosteroids, or mammalian target of rapamycin inhibitors. New onset diabetes mellitus after transplantation (NODAT) is a serious and common complication following solid organ transplantation. NODAT has been reported to occur in 2% to 53% of all solid organ transplants. Kidney transplant recipients who develop NODAT have variably been reported to be at increased risk of fatal and nonfatal cardiovascular events and other adverse outcomes including infection, reduced patient survival, graft rejection, and accelerated graft loss compared with those who do not develop diabetes. Identification of high-risk patients and implementation of measures to reduce the development of NODAT may improve long-term patient and graft outcome. The following article presents an overview of the literature on the current diagnostic criteria for NODAT, its incidence after solid organ transplantation, suggested risk factors and potential pathogenic mechanisms. The impact of NODAT on patient and allograft outcomes and suggested guidelines for early identification and management of NODAT will also be discussed.Keywords: new onset diabetes after transplantation (NODAT), cyclosporine, tacrolimus, sirolimus, hepatitis C and diabetes, cytomegalovirus and diabetesPham PTPham PMPham SVPham PAPham PCDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2011, Iss default, Pp 175-186 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Pham PT Pham PM Pham SV Pham PA Pham PC New onset diabetes after transplantation (NODAT): an overview
description	Phuong-Thu T Pham1, Phuong-Mai T Pham2,3, Son V Pham4, Phuong-Anh T Pham5, Phuong-Chi T Pham2,61Nephrology Division, Kidney Transplant Program, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2David Geffen School of Medicine at UCLA, Los Angeles, CA; 3Department of Medicine, Greater Los Angeles VA Medical Center, Los Angeles, CA; 4Division of Cardiology, Bay Pines VA Medical Center, Bay Pines, FL; 5Division of Cardiology, Memphis VA Medical Center, Memphis, TN; 6Department of Medicine, Nephrology Division, UCLA Olive View Medical Center, Los Angeles, CA, USAAbstract: Although renal transplantation ameliorates cardiovascular risk factors by restoring renal function, it introduces new cardiovascular risks including impaired glucose tolerance or diabetes mellitus, hypertension, and dyslipidemia that are derived, in part, from immunosuppressive medications such as calcineurin inhibitors, corticosteroids, or mammalian target of rapamycin inhibitors. New onset diabetes mellitus after transplantation (NODAT) is a serious and common complication following solid organ transplantation. NODAT has been reported to occur in 2% to 53% of all solid organ transplants. Kidney transplant recipients who develop NODAT have variably been reported to be at increased risk of fatal and nonfatal cardiovascular events and other adverse outcomes including infection, reduced patient survival, graft rejection, and accelerated graft loss compared with those who do not develop diabetes. Identification of high-risk patients and implementation of measures to reduce the development of NODAT may improve long-term patient and graft outcome. The following article presents an overview of the literature on the current diagnostic criteria for NODAT, its incidence after solid organ transplantation, suggested risk factors and potential pathogenic mechanisms. The impact of NODAT on patient and allograft outcomes and suggested guidelines for early identification and management of NODAT will also be discussed.Keywords: new onset diabetes after transplantation (NODAT), cyclosporine, tacrolimus, sirolimus, hepatitis C and diabetes, cytomegalovirus and diabetes
format	article
author	Pham PT Pham PM Pham SV Pham PA Pham PC
author_facet	Pham PT Pham PM Pham SV Pham PA Pham PC
author_sort	Pham PT
title	New onset diabetes after transplantation (NODAT): an overview
title_short	New onset diabetes after transplantation (NODAT): an overview
title_full	New onset diabetes after transplantation (NODAT): an overview
title_fullStr	New onset diabetes after transplantation (NODAT): an overview
title_full_unstemmed	New onset diabetes after transplantation (NODAT): an overview
title_sort	new onset diabetes after transplantation (nodat): an overview
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/72fe5862bc054eaf813ad65e9b0db2b7
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New onset diabetes after transplantation (NODAT): an overview

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