Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.

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Autores principales:	Ling Guo, Shi Luo, Zhengwu Du, Meiling Zhou, Peiwen Li, Yao Fu, Xun Sun, Yuan Huang, Zhirong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73009a82a13f4c91a1bd73fd7e36f4c0
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spelling	oai:doaj.org-article:73009a82a13f4c91a1bd73fd7e36f4c02021-12-02T15:36:58ZTargeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis10.1038/s41467-017-00834-82041-1723https://doaj.org/article/73009a82a13f4c91a1bd73fd7e36f4c02017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00834-8https://doaj.org/toc/2041-1723Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.Ling GuoShi LuoZhengwu DuMeiling ZhouPeiwen LiYao FuXun SunYuan HuangZhirong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ling Guo Shi Luo Zhengwu Du Meiling Zhou Peiwen Li Yao Fu Xun Sun Yuan Huang Zhirong Zhang Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
description	Mesangial cell-mediated glomerulonephritis is a frequent cause of kidney disease. Here the authors show that celastrol loaded in albumin nanoparticles efficiently targets mesangial cells, and is effective in rat models.
format	article
author	Ling Guo Shi Luo Zhengwu Du Meiling Zhou Peiwen Li Yao Fu Xun Sun Yuan Huang Zhirong Zhang
author_facet	Ling Guo Shi Luo Zhengwu Du Meiling Zhou Peiwen Li Yao Fu Xun Sun Yuan Huang Zhirong Zhang
author_sort	Ling Guo
title	Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
title_short	Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
title_full	Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
title_fullStr	Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
title_full_unstemmed	Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
title_sort	targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/73009a82a13f4c91a1bd73fd7e36f4c0
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Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

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