Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice

Embryonic stem cell pluripotency depends upon precise regulation by a core transcription network. Here the authors show that polyglutamylation mediated stabilization of the transcription factor Klf4 by TTLL1 and TTLL4 promotes reprogramming, pluripotency and preimplantation embryonic development.

Guardado en:

Detalles Bibliográficos
Autores principales:	Buqing Ye, Benyu Liu, Lu Hao, Xiaoxiao Zhu, Liuliu Yang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Xiwen Qin, Yanying Wang, Xinlong Yan, Chong Li, Junfeng Hao, Pingping Zhu, Luyun He, Yong Tian, Zusen Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/73012c1b32144569b6f62721f4a3512b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:73012c1b32144569b6f62721f4a3512b
record_format	dspace
spelling	oai:doaj.org-article:73012c1b32144569b6f62721f4a3512b2021-12-02T14:38:48ZKlf4 glutamylation is required for cell reprogramming and early embryonic development in mice10.1038/s41467-018-03008-22041-1723https://doaj.org/article/73012c1b32144569b6f62721f4a3512b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03008-2https://doaj.org/toc/2041-1723Embryonic stem cell pluripotency depends upon precise regulation by a core transcription network. Here the authors show that polyglutamylation mediated stabilization of the transcription factor Klf4 by TTLL1 and TTLL4 promotes reprogramming, pluripotency and preimplantation embryonic development.Buqing YeBenyu LiuLu HaoXiaoxiao ZhuLiuliu YangShuo WangPengyan XiaYing DuShu MengGuanling HuangXiwen QinYanying WangXinlong YanChong LiJunfeng HaoPingping ZhuLuyun HeYong TianZusen FanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Buqing Ye Benyu Liu Lu Hao Xiaoxiao Zhu Liuliu Yang Shuo Wang Pengyan Xia Ying Du Shu Meng Guanling Huang Xiwen Qin Yanying Wang Xinlong Yan Chong Li Junfeng Hao Pingping Zhu Luyun He Yong Tian Zusen Fan Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
description	Embryonic stem cell pluripotency depends upon precise regulation by a core transcription network. Here the authors show that polyglutamylation mediated stabilization of the transcription factor Klf4 by TTLL1 and TTLL4 promotes reprogramming, pluripotency and preimplantation embryonic development.
format	article
author	Buqing Ye Benyu Liu Lu Hao Xiaoxiao Zhu Liuliu Yang Shuo Wang Pengyan Xia Ying Du Shu Meng Guanling Huang Xiwen Qin Yanying Wang Xinlong Yan Chong Li Junfeng Hao Pingping Zhu Luyun He Yong Tian Zusen Fan
author_facet	Buqing Ye Benyu Liu Lu Hao Xiaoxiao Zhu Liuliu Yang Shuo Wang Pengyan Xia Ying Du Shu Meng Guanling Huang Xiwen Qin Yanying Wang Xinlong Yan Chong Li Junfeng Hao Pingping Zhu Luyun He Yong Tian Zusen Fan
author_sort	Buqing Ye
title	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
title_short	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
title_full	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
title_fullStr	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
title_full_unstemmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
title_sort	klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/73012c1b32144569b6f62721f4a3512b
work_keys_str_mv	AT buqingye klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT benyuliu klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT luhao klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT xiaoxiaozhu klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT liuliuyang klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT shuowang klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT pengyanxia klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT yingdu klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT shumeng klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT guanlinghuang klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT xiwenqin klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT yanyingwang klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT xinlongyan klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT chongli klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT junfenghao klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT pingpingzhu klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT luyunhe klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT yongtian klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice AT zusenfan klf4glutamylationisrequiredforcellreprogrammingandearlyembryonicdevelopmentinmice
_version_	1718390841817432064

Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice

Ejemplares similares