Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making
Behavioral flexibility, the ability to modify behavior according to changing conditions, is essential to optimize decision-making. Deficits in behavioral flexibility that persist into adulthood are one consequence of adolescent alcohol exposure, and another is decreased functional connectivity in br...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:7304f24861974a359b8ff3c5171c669f2021-12-01T12:03:29ZAltered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making1663-981210.3389/fphar.2021.778884https://doaj.org/article/7304f24861974a359b8ff3c5171c669f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.778884/fullhttps://doaj.org/toc/1663-9812Behavioral flexibility, the ability to modify behavior according to changing conditions, is essential to optimize decision-making. Deficits in behavioral flexibility that persist into adulthood are one consequence of adolescent alcohol exposure, and another is decreased functional connectivity in brain structures involved in decision-making; however, a link between these two outcomes has not been established. We assessed effects of adolescent alcohol and sex on both Pavlovian and instrumental behaviors and resting-state functional connectivity MRI in adult animals to determine associations between behavioral flexibility and resting-state functional connectivity. Alcohol exposure impaired attentional set reversals and decreased functional connectivity among cortical and subcortical regions-of-interest that underlie flexible behavior. Moreover, mediation analyses indicated that adolescent alcohol-induced reductions in functional connectivity within a subnetwork of affected brain regions statistically mediated errors committed during reversal learning. These results provide a novel link between persistent reductions in brain functional connectivity and deficits in behavioral flexibility resulting from adolescent alcohol exposure.Alexander Gómez-ACarol A. DannenhofferAmanda EltonAmanda EltonSung-Ho LeeSung-Ho LeeWoomi BanYen-Yu Ian ShihYen-Yu Ian ShihYen-Yu Ian ShihYen-Yu Ian ShihCharlotte A. BoettigerCharlotte A. BoettigerCharlotte A. BoettigerCharlotte A. BoettigerDonita L. RobinsonDonita L. RobinsonDonita L. RobinsonFrontiers Media S.A.articleadolescencealcoholPavlovian conditioned approachbehavioral flexibilityfMRITherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021) |
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adolescence alcohol Pavlovian conditioned approach behavioral flexibility fMRI Therapeutics. Pharmacology RM1-950 |
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adolescence alcohol Pavlovian conditioned approach behavioral flexibility fMRI Therapeutics. Pharmacology RM1-950 Alexander Gómez-A Carol A. Dannenhoffer Amanda Elton Amanda Elton Sung-Ho Lee Sung-Ho Lee Woomi Ban Yen-Yu Ian Shih Yen-Yu Ian Shih Yen-Yu Ian Shih Yen-Yu Ian Shih Charlotte A. Boettiger Charlotte A. Boettiger Charlotte A. Boettiger Charlotte A. Boettiger Donita L. Robinson Donita L. Robinson Donita L. Robinson Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making |
| description |
Behavioral flexibility, the ability to modify behavior according to changing conditions, is essential to optimize decision-making. Deficits in behavioral flexibility that persist into adulthood are one consequence of adolescent alcohol exposure, and another is decreased functional connectivity in brain structures involved in decision-making; however, a link between these two outcomes has not been established. We assessed effects of adolescent alcohol and sex on both Pavlovian and instrumental behaviors and resting-state functional connectivity MRI in adult animals to determine associations between behavioral flexibility and resting-state functional connectivity. Alcohol exposure impaired attentional set reversals and decreased functional connectivity among cortical and subcortical regions-of-interest that underlie flexible behavior. Moreover, mediation analyses indicated that adolescent alcohol-induced reductions in functional connectivity within a subnetwork of affected brain regions statistically mediated errors committed during reversal learning. These results provide a novel link between persistent reductions in brain functional connectivity and deficits in behavioral flexibility resulting from adolescent alcohol exposure. |
| format |
article |
| author |
Alexander Gómez-A Carol A. Dannenhoffer Amanda Elton Amanda Elton Sung-Ho Lee Sung-Ho Lee Woomi Ban Yen-Yu Ian Shih Yen-Yu Ian Shih Yen-Yu Ian Shih Yen-Yu Ian Shih Charlotte A. Boettiger Charlotte A. Boettiger Charlotte A. Boettiger Charlotte A. Boettiger Donita L. Robinson Donita L. Robinson Donita L. Robinson |
| author_facet |
Alexander Gómez-A Carol A. Dannenhoffer Amanda Elton Amanda Elton Sung-Ho Lee Sung-Ho Lee Woomi Ban Yen-Yu Ian Shih Yen-Yu Ian Shih Yen-Yu Ian Shih Yen-Yu Ian Shih Charlotte A. Boettiger Charlotte A. Boettiger Charlotte A. Boettiger Charlotte A. Boettiger Donita L. Robinson Donita L. Robinson Donita L. Robinson |
| author_sort |
Alexander Gómez-A |
| title |
Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making |
| title_short |
Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making |
| title_full |
Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making |
| title_fullStr |
Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making |
| title_full_unstemmed |
Altered Cortico-Subcortical Network After Adolescent Alcohol Exposure Mediates Behavioral Deficits in Flexible Decision-Making |
| title_sort |
altered cortico-subcortical network after adolescent alcohol exposure mediates behavioral deficits in flexible decision-making |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/7304f24861974a359b8ff3c5171c669f |
| work_keys_str_mv |
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