Altered Cerebellar Biochemical Profiles in Infants Born Prematurely

Abstract This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy (1H-MRS). We explore the associations between altered cerebellar metabolite profiles and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marie Brossard-Racine, Jonathan Murnick, Marine Bouyssi-Kobar, Janie Coulombe, Taeun Chang, Catherine Limperopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73053108eb394df192c54d586c18e3e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:73053108eb394df192c54d586c18e3e7
record_format	dspace
spelling	oai:doaj.org-article:73053108eb394df192c54d586c18e3e72021-12-02T15:05:05ZAltered Cerebellar Biochemical Profiles in Infants Born Prematurely10.1038/s41598-017-08195-42045-2322https://doaj.org/article/73053108eb394df192c54d586c18e3e72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08195-4https://doaj.org/toc/2045-2322Abstract This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy (1H-MRS). We explore the associations between altered cerebellar metabolite profiles and brain injury topography, severity of injury, and prematurity-related clinical complications. We prospectively collected high quality 1H-MRS in 59 premature infants born ≤32 weeks and 61 healthy full term controls. 1H-MRS data were processed using LCModel software to calculate absolute metabolite concentration for N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr). PT infants had significantly lower cerebellar NAA (p < 0.025) and higher Cho (p < 0.001) at TEA when compared to healthy controls. Creatine was not different between the two groups. The presence of cerebellar injury was consistently associated with reduced concentrations for NAA, Cho, and Cr. Postnatal infection was negatively associated with NAA and Cr (p < 005), while cerebral cortical brain injury severity was inversely associated with both Cho and Cr (p < 0.01). We report for the first time that premature birth is associated with altered cerebellar metabolite profiles when compared to term born controls. Infection, cerebellar injury and supratentorial injury are important risk factors for impaired preterm cerebellar biochemistry.Marie Brossard-RacineJonathan MurnickMarine Bouyssi-KobarJanie CoulombeTaeun ChangCatherine LimperopoulosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie Brossard-Racine Jonathan Murnick Marine Bouyssi-Kobar Janie Coulombe Taeun Chang Catherine Limperopoulos Altered Cerebellar Biochemical Profiles in Infants Born Prematurely
description	Abstract This study aims to compare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (TEA) and healthy full-term newborns using proton magnetic resonance spectroscopy (1H-MRS). We explore the associations between altered cerebellar metabolite profiles and brain injury topography, severity of injury, and prematurity-related clinical complications. We prospectively collected high quality 1H-MRS in 59 premature infants born ≤32 weeks and 61 healthy full term controls. 1H-MRS data were processed using LCModel software to calculate absolute metabolite concentration for N-acetyl-aspartate (NAA), choline (Cho) and creatine (Cr). PT infants had significantly lower cerebellar NAA (p < 0.025) and higher Cho (p < 0.001) at TEA when compared to healthy controls. Creatine was not different between the two groups. The presence of cerebellar injury was consistently associated with reduced concentrations for NAA, Cho, and Cr. Postnatal infection was negatively associated with NAA and Cr (p < 005), while cerebral cortical brain injury severity was inversely associated with both Cho and Cr (p < 0.01). We report for the first time that premature birth is associated with altered cerebellar metabolite profiles when compared to term born controls. Infection, cerebellar injury and supratentorial injury are important risk factors for impaired preterm cerebellar biochemistry.
format	article
author	Marie Brossard-Racine Jonathan Murnick Marine Bouyssi-Kobar Janie Coulombe Taeun Chang Catherine Limperopoulos
author_facet	Marie Brossard-Racine Jonathan Murnick Marine Bouyssi-Kobar Janie Coulombe Taeun Chang Catherine Limperopoulos
author_sort	Marie Brossard-Racine
title	Altered Cerebellar Biochemical Profiles in Infants Born Prematurely
title_short	Altered Cerebellar Biochemical Profiles in Infants Born Prematurely
title_full	Altered Cerebellar Biochemical Profiles in Infants Born Prematurely
title_fullStr	Altered Cerebellar Biochemical Profiles in Infants Born Prematurely
title_full_unstemmed	Altered Cerebellar Biochemical Profiles in Infants Born Prematurely
title_sort	altered cerebellar biochemical profiles in infants born prematurely
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/73053108eb394df192c54d586c18e3e7
work_keys_str_mv	AT mariebrossardracine alteredcerebellarbiochemicalprofilesininfantsbornprematurely AT jonathanmurnick alteredcerebellarbiochemicalprofilesininfantsbornprematurely AT marinebouyssikobar alteredcerebellarbiochemicalprofilesininfantsbornprematurely AT janiecoulombe alteredcerebellarbiochemicalprofilesininfantsbornprematurely AT taeunchang alteredcerebellarbiochemicalprofilesininfantsbornprematurely AT catherinelimperopoulos alteredcerebellarbiochemicalprofilesininfantsbornprematurely
_version_	1718388962322546688

Altered Cerebellar Biochemical Profiles in Infants Born Prematurely

Ejemplares similares