TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice
TRPV1 is known to be expressed in peripheral structures and the spinal cord, especially for pain processing. Here the authors show that in the brain, in particular the anterior cingulate cortex, TRPV1 is functionally expressed in microglia; stimulation of TRPV1 activates microglia, which in turn aff...
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Nature Portfolio
2017
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oai:doaj.org-article:7307a1d610ce4e82b01283b5df42f5412021-12-02T15:38:46ZTRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice10.1038/ncomms152922041-1723https://doaj.org/article/7307a1d610ce4e82b01283b5df42f5412017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15292https://doaj.org/toc/2041-1723TRPV1 is known to be expressed in peripheral structures and the spinal cord, especially for pain processing. Here the authors show that in the brain, in particular the anterior cingulate cortex, TRPV1 is functionally expressed in microglia; stimulation of TRPV1 activates microglia, which in turn affects glutamatergic neurotransmission.Maria Cristina MarroneAnnunziato MorabitoMichela GiustizieriValerio ChiurchiùAlessandro LeutiMarzia MattioliSara MarinelliLoredana RigantiMarta LombardiEmanuele MuranaAntonio TotaroDaniele PiomelliDavide RagozzinoSergio OddiMauro MaccarroneClaudia VerderioSilvia MarinelliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Maria Cristina Marrone Annunziato Morabito Michela Giustizieri Valerio Chiurchiù Alessandro Leuti Marzia Mattioli Sara Marinelli Loredana Riganti Marta Lombardi Emanuele Murana Antonio Totaro Daniele Piomelli Davide Ragozzino Sergio Oddi Mauro Maccarrone Claudia Verderio Silvia Marinelli TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice |
| description |
TRPV1 is known to be expressed in peripheral structures and the spinal cord, especially for pain processing. Here the authors show that in the brain, in particular the anterior cingulate cortex, TRPV1 is functionally expressed in microglia; stimulation of TRPV1 activates microglia, which in turn affects glutamatergic neurotransmission. |
| format |
article |
| author |
Maria Cristina Marrone Annunziato Morabito Michela Giustizieri Valerio Chiurchiù Alessandro Leuti Marzia Mattioli Sara Marinelli Loredana Riganti Marta Lombardi Emanuele Murana Antonio Totaro Daniele Piomelli Davide Ragozzino Sergio Oddi Mauro Maccarrone Claudia Verderio Silvia Marinelli |
| author_facet |
Maria Cristina Marrone Annunziato Morabito Michela Giustizieri Valerio Chiurchiù Alessandro Leuti Marzia Mattioli Sara Marinelli Loredana Riganti Marta Lombardi Emanuele Murana Antonio Totaro Daniele Piomelli Davide Ragozzino Sergio Oddi Mauro Maccarrone Claudia Verderio Silvia Marinelli |
| author_sort |
Maria Cristina Marrone |
| title |
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice |
| title_short |
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice |
| title_full |
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice |
| title_fullStr |
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice |
| title_full_unstemmed |
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice |
| title_sort |
trpv1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/7307a1d610ce4e82b01283b5df42f541 |
| work_keys_str_mv |
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1718386118788907008 |