Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
Multidrug-resistant bacteria are a real threat to human health. Here, the authors investigate a combinatory strategy using blue-laser and thymol against Staphylococcus aureus and Pseudomonas aeruginosa. Blue-laser and thymol succesfully sterilized acute infected or biofilm-associated wounds and prev...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/730d8cbc56764cae9a77f36ac77a7064 |
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| Sumario: | Multidrug-resistant bacteria are a real threat to human health. Here, the authors investigate a combinatory strategy using blue-laser and thymol against Staphylococcus aureus and Pseudomonas aeruginosa. Blue-laser and thymol succesfully sterilized acute infected or biofilm-associated wounds and prevented systematic dissemination in mice. Compared with mammalian cells, bacteria contain abundant proporphyrin-like compounds that transform harmless thymol into blue-laser sensitizers, thymoquinone and thymohydroquinone. Photo-excitation of thymoquinone and thymohydroquinone augmented reactive oxygen species production in bacteria while completely sparing the host tissue. |
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