Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa

Multidrug-resistant bacteria are a real threat to human health. Here, the authors investigate a combinatory strategy using blue-laser and thymol against Staphylococcus aureus and Pseudomonas aeruginosa. Blue-laser and thymol succesfully sterilized acute infected or biofilm-associated wounds and prev...

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Autores principales:	Min Lu, Yongli Li, Mei X. Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/730d8cbc56764cae9a77f36ac77a7064
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spelling	oai:doaj.org-article:730d8cbc56764cae9a77f36ac77a70642021-12-02T16:35:55ZBacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa10.1038/s42003-021-01956-y2399-3642https://doaj.org/article/730d8cbc56764cae9a77f36ac77a70642021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01956-yhttps://doaj.org/toc/2399-3642Multidrug-resistant bacteria are a real threat to human health. Here, the authors investigate a combinatory strategy using blue-laser and thymol against Staphylococcus aureus and Pseudomonas aeruginosa. Blue-laser and thymol succesfully sterilized acute infected or biofilm-associated wounds and prevented systematic dissemination in mice. Compared with mammalian cells, bacteria contain abundant proporphyrin-like compounds that transform harmless thymol into blue-laser sensitizers, thymoquinone and thymohydroquinone. Photo-excitation of thymoquinone and thymohydroquinone augmented reactive oxygen species production in bacteria while completely sparing the host tissue.Min LuYongli LiMei X. WuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Min Lu Yongli Li Mei X. Wu Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
description	Multidrug-resistant bacteria are a real threat to human health. Here, the authors investigate a combinatory strategy using blue-laser and thymol against Staphylococcus aureus and Pseudomonas aeruginosa. Blue-laser and thymol succesfully sterilized acute infected or biofilm-associated wounds and prevented systematic dissemination in mice. Compared with mammalian cells, bacteria contain abundant proporphyrin-like compounds that transform harmless thymol into blue-laser sensitizers, thymoquinone and thymohydroquinone. Photo-excitation of thymoquinone and thymohydroquinone augmented reactive oxygen species production in bacteria while completely sparing the host tissue.
format	article
author	Min Lu Yongli Li Mei X. Wu
author_facet	Min Lu Yongli Li Mei X. Wu
author_sort	Min Lu
title	Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
title_short	Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
title_full	Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
title_fullStr	Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
title_full_unstemmed	Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa
title_sort	bacteria-specific pro-photosensitizer kills multidrug-resistant staphylococcus aureus and pseudomonas aeruginosa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/730d8cbc56764cae9a77f36ac77a7064
work_keys_str_mv	AT minlu bacteriaspecificprophotosensitizerkillsmultidrugresistantstaphylococcusaureusandpseudomonasaeruginosa AT yonglili bacteriaspecificprophotosensitizerkillsmultidrugresistantstaphylococcusaureusandpseudomonasaeruginosa AT meixwu bacteriaspecificprophotosensitizerkillsmultidrugresistantstaphylococcusaureusandpseudomonasaeruginosa
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Bacteria-specific pro-photosensitizer kills multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa

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