A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.

<h4>Purpose</h4>To develop the first normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine.<h4>Methods</h4>This study is a retrospective cross section...

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Autores principales:	Joos Meyer, Roshan Karri, Helen Danesh-Meyer, Kate Drummond, Andrew Symons
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/730ff608165d4701a893eec73c016a9c
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spelling	oai:doaj.org-article:730ff608165d4701a893eec73c016a9c2021-12-02T20:09:48ZA normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.1932-620310.1371/journal.pone.0253720https://doaj.org/article/730ff608165d4701a893eec73c016a9c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253720https://doaj.org/toc/1932-6203<h4>Purpose</h4>To develop the first normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine.<h4>Methods</h4>This study is a retrospective cross sectional analysis of macular and circumpapillary OCT scans of healthy individuals. All participants had a full ophthalmic examination, including best corrected visual acuity, intraocular pressure, biomicroscopy, posterior segment examination and OCT scan. The volume and thickness of each of the nine Early Treatment Diabetic Retinopathy zones at the macula were analysed for the total retinal thickness, retinal nerve fibre layer (RNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL). The thickness of the circumpapillary RNFL was analysed at the disc. Associations between age, gender, refractive error and OCT measurements were explored. De-identified A-scans were extracted from the OCT machine as separate tab-separated text file and made available according to the data sharing statement.<h4>Results</h4>Two-hundred eyes from 146 participants were included of which 69 (47%) were female. The mean age (SD) was 48.52 (17.52). Participants were evenly distributed across four age groups and represented nine broad ethnic groups in proportions comparable to the local distribution. All the macular scans were 20° x 20° (5.9 mm x 5.9 mm), with a total scan density between 12,800 and 49,152 A-scans. The peripapillary scans were all 12° (3.5 mm), at a scan density of 768 A-scans. The mean retinal, GCL and IPL volumes were significantly greater in males than females. Mean peripapillary RNFL thickness did not differ significantly between males and females. Age and total retinal volume (r = -0.2561, P = 0.0003), GCL volume (-0.2911, P < 0.0001) and IPL volume (-0.3194, P < 0.0001) were negatively correlated. The IPL had the strongest three significant negatively associated segments; superior inner IPL (r = -0.3444, P < 0.0001), nasal outer IPL (r = -0.3217, P < 0.0001) and inferior inner IPL (r = -0.3179, P < 0.0001). The temporal inner macular RNFL showed a statistically significant positive correlation (r = 0.1929, P = 0.0062) with age. The only significant association between age and thickness at the peripapillary disc scan was the superior temporal sector (r = -0.1910, P = 0.0067). All retinal layers were negatively correlated for refractive error, except for the central RNFL which was positively correlated (r = 0.1426, P = 0.044).<h4>Conclusion</h4>This study provides a normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine.Joos MeyerRoshan KarriHelen Danesh-MeyerKate DrummondAndrew SymonsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253720 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joos Meyer Roshan Karri Helen Danesh-Meyer Kate Drummond Andrew Symons A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.
description	<h4>Purpose</h4>To develop the first normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine.<h4>Methods</h4>This study is a retrospective cross sectional analysis of macular and circumpapillary OCT scans of healthy individuals. All participants had a full ophthalmic examination, including best corrected visual acuity, intraocular pressure, biomicroscopy, posterior segment examination and OCT scan. The volume and thickness of each of the nine Early Treatment Diabetic Retinopathy zones at the macula were analysed for the total retinal thickness, retinal nerve fibre layer (RNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL). The thickness of the circumpapillary RNFL was analysed at the disc. Associations between age, gender, refractive error and OCT measurements were explored. De-identified A-scans were extracted from the OCT machine as separate tab-separated text file and made available according to the data sharing statement.<h4>Results</h4>Two-hundred eyes from 146 participants were included of which 69 (47%) were female. The mean age (SD) was 48.52 (17.52). Participants were evenly distributed across four age groups and represented nine broad ethnic groups in proportions comparable to the local distribution. All the macular scans were 20° x 20° (5.9 mm x 5.9 mm), with a total scan density between 12,800 and 49,152 A-scans. The peripapillary scans were all 12° (3.5 mm), at a scan density of 768 A-scans. The mean retinal, GCL and IPL volumes were significantly greater in males than females. Mean peripapillary RNFL thickness did not differ significantly between males and females. Age and total retinal volume (r = -0.2561, P = 0.0003), GCL volume (-0.2911, P < 0.0001) and IPL volume (-0.3194, P < 0.0001) were negatively correlated. The IPL had the strongest three significant negatively associated segments; superior inner IPL (r = -0.3444, P < 0.0001), nasal outer IPL (r = -0.3217, P < 0.0001) and inferior inner IPL (r = -0.3179, P < 0.0001). The temporal inner macular RNFL showed a statistically significant positive correlation (r = 0.1929, P = 0.0062) with age. The only significant association between age and thickness at the peripapillary disc scan was the superior temporal sector (r = -0.1910, P = 0.0067). All retinal layers were negatively correlated for refractive error, except for the central RNFL which was positively correlated (r = 0.1426, P = 0.044).<h4>Conclusion</h4>This study provides a normative database of macular and circumpapillary scans with reference values at the level of the A-scan using the Heidelberg Spectralis Optical Coherence Tomography (OCT) machine.
format	article
author	Joos Meyer Roshan Karri Helen Danesh-Meyer Kate Drummond Andrew Symons
author_facet	Joos Meyer Roshan Karri Helen Danesh-Meyer Kate Drummond Andrew Symons
author_sort	Joos Meyer
title	A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.
title_short	A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.
title_full	A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.
title_fullStr	A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.
title_full_unstemmed	A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.
title_sort	normative database of a-scan data using the heidelberg spectralis spectral domain optical coherence tomography machine.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/730ff608165d4701a893eec73c016a9c
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A normative database of A-scan data using the Heidelberg Spectralis Spectral Domain Optical Coherence Tomography machine.

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