Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis

Asad F Durrani,1 Peter Y Zhao,1 Yunshu Zhou,1 Michael Huvard,2 Lyna Azzouz,3 Jason M Keil,3 Stephen T Armenti,1 Vaidehi S Dedania,4 David C Musch,1,5 David N Zacks1 1Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA; 2Department of O...

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Autores principales:	Durrani AF, Zhao PY, Zhou Y, Huvard M, Azzouz L, Keil JM, Armenti ST, Dedania VS, Musch DC, Zacks DN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	endophthalmitis intraocular foreign body ocular trauma open globe injury Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7310befa42f749dc86a52c5af7c61609
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spelling	oai:doaj.org-article:7310befa42f749dc86a52c5af7c616092021-12-02T15:55:50ZRisk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis1177-5483https://doaj.org/article/7310befa42f749dc86a52c5af7c616092021-05-01T00:00:00Zhttps://www.dovepress.com/risk-factors-for-endophthalmitis-following-open-globe-injuries-a-17-ye-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Asad F Durrani,1 Peter Y Zhao,1 Yunshu Zhou,1 Michael Huvard,2 Lyna Azzouz,3 Jason M Keil,3 Stephen T Armenti,1 Vaidehi S Dedania,4 David C Musch,1,5 David N Zacks1 1Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA; 2Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA; 3University of Michigan Medical School, Ann Arbor, MI, USA; 4Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA; 5Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USACorrespondence: David N ZacksDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI, 48105, USATel +1 734-232-8404Email Davzacks@med.umich.eduBackground/Aims: To determine the rate of endophthalmitis and assess risk factors for development of endophthalmitis following open globe injury (OGI).Methods: A retrospective chart review of all patients treated for OGI at the University of Michigan from January 2000 to July 2017 was conducted. Exclusion criteria included intravitreal injection or intraocular surgery in the 30 days prior to injury or less than 30 days of follow-up. A total of 586 out of 993 open globe injuries were included in the study. The main outcome measure was the rate of endophthalmitis.Results: In this study, 25/586 eyes (4.3%) had endophthalmitis. Of these, 12/25 eyes (48.0%) presented with endophthalmitis and 13/25 eyes (52.0%) developed endophthalmitis after globe closure. Multivariate analysis identified time to globe repair (OR 4.5, CI 1.9– 10.7, p = 0.0008), zone I injury (OR 3.6, CI 1.1– 11.0, p = 0.0282), and need for additional surgery (OR 5.5, CI 1.5– 19.7, p = 0.0092) as factors associated with increased risk of developing endophthalmitis. Subconjunctival antibiotic injection at the time of globe closure (OR 0.3, CI 0.1– 0.7, p = 0.0036) was associated with decreased risk of developing endophthalmitis.Conclusion: Prompt globe closure and subconjunctival antibiotics may reduce the risk of endophthalmitis in OGI. Furthermore, our practice of a one-time dose of systemic prophylactic antibiotics, and intravitreal antibiotics if intraocular foreign body (IOFB) removal is delayed, was not found to increase the rate of endophthalmitis.Keywords: endophthalmitis, intraocular foreign body, ocular trauma, open globe injuryDurrani AFZhao PYZhou YHuvard MAzzouz LKeil JMArmenti STDedania VSMusch DCZacks DNDove Medical Pressarticleendophthalmitisintraocular foreign bodyocular traumaopen globe injuryOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2077-2087 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endophthalmitis intraocular foreign body ocular trauma open globe injury Ophthalmology RE1-994
spellingShingle	endophthalmitis intraocular foreign body ocular trauma open globe injury Ophthalmology RE1-994 Durrani AF Zhao PY Zhou Y Huvard M Azzouz L Keil JM Armenti ST Dedania VS Musch DC Zacks DN Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis
description	Asad F Durrani,1 Peter Y Zhao,1 Yunshu Zhou,1 Michael Huvard,2 Lyna Azzouz,3 Jason M Keil,3 Stephen T Armenti,1 Vaidehi S Dedania,4 David C Musch,1,5 David N Zacks1 1Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA; 2Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA; 3University of Michigan Medical School, Ann Arbor, MI, USA; 4Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA; 5Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USACorrespondence: David N ZacksDepartment of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI, 48105, USATel +1 734-232-8404Email Davzacks@med.umich.eduBackground/Aims: To determine the rate of endophthalmitis and assess risk factors for development of endophthalmitis following open globe injury (OGI).Methods: A retrospective chart review of all patients treated for OGI at the University of Michigan from January 2000 to July 2017 was conducted. Exclusion criteria included intravitreal injection or intraocular surgery in the 30 days prior to injury or less than 30 days of follow-up. A total of 586 out of 993 open globe injuries were included in the study. The main outcome measure was the rate of endophthalmitis.Results: In this study, 25/586 eyes (4.3%) had endophthalmitis. Of these, 12/25 eyes (48.0%) presented with endophthalmitis and 13/25 eyes (52.0%) developed endophthalmitis after globe closure. Multivariate analysis identified time to globe repair (OR 4.5, CI 1.9– 10.7, p = 0.0008), zone I injury (OR 3.6, CI 1.1– 11.0, p = 0.0282), and need for additional surgery (OR 5.5, CI 1.5– 19.7, p = 0.0092) as factors associated with increased risk of developing endophthalmitis. Subconjunctival antibiotic injection at the time of globe closure (OR 0.3, CI 0.1– 0.7, p = 0.0036) was associated with decreased risk of developing endophthalmitis.Conclusion: Prompt globe closure and subconjunctival antibiotics may reduce the risk of endophthalmitis in OGI. Furthermore, our practice of a one-time dose of systemic prophylactic antibiotics, and intravitreal antibiotics if intraocular foreign body (IOFB) removal is delayed, was not found to increase the rate of endophthalmitis.Keywords: endophthalmitis, intraocular foreign body, ocular trauma, open globe injury
format	article
author	Durrani AF Zhao PY Zhou Y Huvard M Azzouz L Keil JM Armenti ST Dedania VS Musch DC Zacks DN
author_facet	Durrani AF Zhao PY Zhou Y Huvard M Azzouz L Keil JM Armenti ST Dedania VS Musch DC Zacks DN
author_sort	Durrani AF
title	Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis
title_short	Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis
title_full	Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis
title_fullStr	Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis
title_full_unstemmed	Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis
title_sort	risk factors for endophthalmitis following open globe injuries: a 17-year analysis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7310befa42f749dc86a52c5af7c61609
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_version_	1718385398899539968

Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis

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