Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences

Jiao Wang, Jixiong Xu Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaCorrespondence: Jixiong XuDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, No. 17 Yongwaizhen...

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Autores principales:	Wang J, Xu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	wound healing insulin therapy review Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/731381433d2f4f29860660ddf6b8561f
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spelling	oai:doaj.org-article:731381433d2f4f29860660ddf6b8561f2021-12-02T11:53:37ZEffects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences1178-7007https://doaj.org/article/731381433d2f4f29860660ddf6b8561f2020-03-01T00:00:00Zhttps://www.dovepress.com/effects-of-topical-insulin-on-wound-healing-a-review-of-animal-and-hum-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jiao Wang, Jixiong Xu Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaCorrespondence: Jixiong XuDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng St., Nanchang, Jiangxi Province 330006, People’s Republic of ChinaTel +86 13307086069Email Jixiong.Xu@ncu.edu.cnAbstract: Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.Keywords: wound healing, insulin therapy, reviewWang JXu JDove Medical Pressarticlewound healinginsulin therapyreviewSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 719-727 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	wound healing insulin therapy review Specialties of internal medicine RC581-951
spellingShingle	wound healing insulin therapy review Specialties of internal medicine RC581-951 Wang J Xu J Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences
description	Jiao Wang, Jixiong Xu Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of ChinaCorrespondence: Jixiong XuDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng St., Nanchang, Jiangxi Province 330006, People’s Republic of ChinaTel +86 13307086069Email Jixiong.Xu@ncu.edu.cnAbstract: Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.Keywords: wound healing, insulin therapy, review
format	article
author	Wang J Xu J
author_facet	Wang J Xu J
author_sort	Wang J
title	Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences
title_short	Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences
title_full	Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences
title_fullStr	Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences
title_full_unstemmed	Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences
title_sort	effects of topical insulin on wound healing: a review of animal and human evidences
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/731381433d2f4f29860660ddf6b8561f
work_keys_str_mv	AT wangj effectsoftopicalinsulinonwoundhealingareviewofanimalandhumanevidences AT xuj effectsoftopicalinsulinonwoundhealingareviewofanimalandhumanevidences
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Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences

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