Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor

Abstract Prothrombin time (PT) and the associated international normalized ratio (INR) are routinely tested to assess the risk of bleeding or thrombosis and to monitor response to anticoagulant therapy in patients. To measure PT/INR, conventional coagulation testing (CCT) is performed, which is time...

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Autores principales:	Markandey M. Tripathi, Satoru Egawa, Alexandra G. Wirth, Diane M. Tshikudi, Elizabeth M. Van Cott, Seemantini K. Nadkarni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73149dcff75a4a04afb9c309be96c36d
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spelling	oai:doaj.org-article:73149dcff75a4a04afb9c309be96c36d2021-12-02T12:30:34ZClinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor10.1038/s41598-017-08693-52045-2322https://doaj.org/article/73149dcff75a4a04afb9c309be96c36d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08693-5https://doaj.org/toc/2045-2322Abstract Prothrombin time (PT) and the associated international normalized ratio (INR) are routinely tested to assess the risk of bleeding or thrombosis and to monitor response to anticoagulant therapy in patients. To measure PT/INR, conventional coagulation testing (CCT) is performed, which is time-consuming and requires the separation of cellular components from whole blood. Here, we report on a portable and battery-operated optical sensor that can rapidly quantify PT/INR within seconds by measuring alterations in the viscoelastic properties of a drop of whole blood following activation of coagulation with thromboplastin. In this study, PT/INR values were measured in 60 patients using the optical sensor and compared with the corresponding CCT values. Our results report a close correlation and high concordance between PT/INR measured using the two approaches. These findings confirm the accuracy of our optical sensing approach for rapid PT/INR testing in whole blood and highlight the potential for use at the point-of-care or for patient self-testing.Markandey M. TripathiSatoru EgawaAlexandra G. WirthDiane M. TshikudiElizabeth M. Van CottSeemantini K. NadkarniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Markandey M. Tripathi Satoru Egawa Alexandra G. Wirth Diane M. Tshikudi Elizabeth M. Van Cott Seemantini K. Nadkarni Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor
description	Abstract Prothrombin time (PT) and the associated international normalized ratio (INR) are routinely tested to assess the risk of bleeding or thrombosis and to monitor response to anticoagulant therapy in patients. To measure PT/INR, conventional coagulation testing (CCT) is performed, which is time-consuming and requires the separation of cellular components from whole blood. Here, we report on a portable and battery-operated optical sensor that can rapidly quantify PT/INR within seconds by measuring alterations in the viscoelastic properties of a drop of whole blood following activation of coagulation with thromboplastin. In this study, PT/INR values were measured in 60 patients using the optical sensor and compared with the corresponding CCT values. Our results report a close correlation and high concordance between PT/INR measured using the two approaches. These findings confirm the accuracy of our optical sensing approach for rapid PT/INR testing in whole blood and highlight the potential for use at the point-of-care or for patient self-testing.
format	article
author	Markandey M. Tripathi Satoru Egawa Alexandra G. Wirth Diane M. Tshikudi Elizabeth M. Van Cott Seemantini K. Nadkarni
author_facet	Markandey M. Tripathi Satoru Egawa Alexandra G. Wirth Diane M. Tshikudi Elizabeth M. Van Cott Seemantini K. Nadkarni
author_sort	Markandey M. Tripathi
title	Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor
title_short	Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor
title_full	Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor
title_fullStr	Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor
title_full_unstemmed	Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor
title_sort	clinical evaluation of whole blood prothrombin time (pt) and international normalized ratio (inr) using a laser speckle rheology sensor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/73149dcff75a4a04afb9c309be96c36d
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Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor

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