Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices

Abstract The specific role of the various pathogens causing cardiac implantable electronic devices-(CIEDs)-related infections requires further understanding. The data of 1241 patients undergoing transvenous lead extraction because of lead-related infective endocarditis (LRIE-773 patients) and pocket...

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Autores principales:	Anna Polewczyk, Wojciech Jacheć, Luca Segreti, Maria Grazia Bongiorni, Andrzej Kutarski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73197d0e97184a458fdaa2b13a1d99f1
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spelling	oai:doaj.org-article:73197d0e97184a458fdaa2b13a1d99f12021-12-02T17:56:56ZInfluence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices10.1038/s41598-021-94168-72045-2322https://doaj.org/article/73197d0e97184a458fdaa2b13a1d99f12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94168-7https://doaj.org/toc/2045-2322Abstract The specific role of the various pathogens causing cardiac implantable electronic devices-(CIEDs)-related infections requires further understanding. The data of 1241 patients undergoing transvenous lead extraction because of lead-related infective endocarditis (LRIE-773 patients) and pocket infection (PI-468 patients) in two high-volume centers were analyzed. Clinical course and long-term prognosis according to the pathogen were assessed. Blood and generator pocket cultures were most often positive for methicillin-sensitive Staphylococcus aureus (MSSA: 22.19% and 18.13% respectively), methicillin-sensitive Staphylococcus epidermidis (MSSE: 17.39% and 15.63%) and other staphylococci (11.59% and 6.46%). The worst long-term prognosis both in LRIE and PI subgroup was in patients with infection caused by Gram-positive microorganisms, other than staphylococci. The most common pathogens causing CIED infection are MSSA and MSSE, however, the role of other Gram-positive bacteria and Gram-negative organisms is also important. Comparable, high mortality in patients with LRIE and PI requires further studies.Anna PolewczykWojciech JachećLuca SegretiMaria Grazia BongiorniAndrzej KutarskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Polewczyk Wojciech Jacheć Luca Segreti Maria Grazia Bongiorni Andrzej Kutarski Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices
description	Abstract The specific role of the various pathogens causing cardiac implantable electronic devices-(CIEDs)-related infections requires further understanding. The data of 1241 patients undergoing transvenous lead extraction because of lead-related infective endocarditis (LRIE-773 patients) and pocket infection (PI-468 patients) in two high-volume centers were analyzed. Clinical course and long-term prognosis according to the pathogen were assessed. Blood and generator pocket cultures were most often positive for methicillin-sensitive Staphylococcus aureus (MSSA: 22.19% and 18.13% respectively), methicillin-sensitive Staphylococcus epidermidis (MSSE: 17.39% and 15.63%) and other staphylococci (11.59% and 6.46%). The worst long-term prognosis both in LRIE and PI subgroup was in patients with infection caused by Gram-positive microorganisms, other than staphylococci. The most common pathogens causing CIED infection are MSSA and MSSE, however, the role of other Gram-positive bacteria and Gram-negative organisms is also important. Comparable, high mortality in patients with LRIE and PI requires further studies.
format	article
author	Anna Polewczyk Wojciech Jacheć Luca Segreti Maria Grazia Bongiorni Andrzej Kutarski
author_facet	Anna Polewczyk Wojciech Jacheć Luca Segreti Maria Grazia Bongiorni Andrzej Kutarski
author_sort	Anna Polewczyk
title	Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices
title_short	Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices
title_full	Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices
title_fullStr	Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices
title_full_unstemmed	Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices
title_sort	influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/73197d0e97184a458fdaa2b13a1d99f1
work_keys_str_mv	AT annapolewczyk influenceofthetypeofpathogenontheclinicalcourseofinfectiouscomplicationsrelatedtocardiacimplantableelectronicdevices AT wojciechjachec influenceofthetypeofpathogenontheclinicalcourseofinfectiouscomplicationsrelatedtocardiacimplantableelectronicdevices AT lucasegreti influenceofthetypeofpathogenontheclinicalcourseofinfectiouscomplicationsrelatedtocardiacimplantableelectronicdevices AT mariagraziabongiorni influenceofthetypeofpathogenontheclinicalcourseofinfectiouscomplicationsrelatedtocardiacimplantableelectronicdevices AT andrzejkutarski influenceofthetypeofpathogenontheclinicalcourseofinfectiouscomplicationsrelatedtocardiacimplantableelectronicdevices
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Influence of the type of pathogen on the clinical course of infectious complications related to cardiac implantable electronic devices

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