Organic Hyperbolic Material Assisted Illumination Nanoscopy

Abstract Resolution capability of the linear structured illumination microscopy (SIM) plays a key role in its applications in physics, medicine, biology, and life science. Many advanced methodologies have been developed to extend the resolution of structured illumination by using subdiffraction‐limi...

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Autores principales:	Yeon Ui Lee, Clara Posner, Zhaoyu Nie, Junxiang Zhao, Shilong Li, Steven Edward Bopp, Gde Bimananda Mahardika Wisna, Jeongho Ha, Chengyu Song, Jin Zhang, Sui Yang, Xiang Zhang, Zhaowei Liu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bioimaging organic hyperbolic materials poly(3‐hexylthiophenes) structured illumination microscopy super‐resolution microscopy Science Q
Acceso en línea:	https://doaj.org/article/731b2c127898434ab79bed849954982d
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spelling	oai:doaj.org-article:731b2c127898434ab79bed849954982d2021-11-17T08:40:31ZOrganic Hyperbolic Material Assisted Illumination Nanoscopy2198-384410.1002/advs.202102230https://doaj.org/article/731b2c127898434ab79bed849954982d2021-11-01T00:00:00Zhttps://doi.org/10.1002/advs.202102230https://doaj.org/toc/2198-3844Abstract Resolution capability of the linear structured illumination microscopy (SIM) plays a key role in its applications in physics, medicine, biology, and life science. Many advanced methodologies have been developed to extend the resolution of structured illumination by using subdiffraction‐limited optical excitation patterns. However, obtaining SIM images with a resolution beyond 40 nm at visible frequency remains as an insurmountable obstacle due to the intrinsic limitation of spatial frequency bandwidth of the involved materials and the complexity of the illumination system. Here, a low‐loss natural organic hyperbolic material (OHM) that can support record high spatial‐frequency modes beyond 50k0, i.e., effective refractive index larger than 50, at visible frequencies is reported. OHM‐based speckle structured illumination microscopy demonstrates imaging resolution at 30 nm scales with enhanced fluorophore photostability, biocompatibility, easy to use and low cost. This study will open up a new route in super‐resolution microscopy by utilizing OHM films for various applications including bioimaging and sensing.Yeon Ui LeeClara PosnerZhaoyu NieJunxiang ZhaoShilong LiSteven Edward BoppGde Bimananda Mahardika WisnaJeongho HaChengyu SongJin ZhangSui YangXiang ZhangZhaowei LiuWileyarticlebioimagingorganic hyperbolic materialspoly(3‐hexylthiophenes)structured illumination microscopysuper‐resolution microscopyScienceQENAdvanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioimaging organic hyperbolic materials poly(3‐hexylthiophenes) structured illumination microscopy super‐resolution microscopy Science Q
spellingShingle	bioimaging organic hyperbolic materials poly(3‐hexylthiophenes) structured illumination microscopy super‐resolution microscopy Science Q Yeon Ui Lee Clara Posner Zhaoyu Nie Junxiang Zhao Shilong Li Steven Edward Bopp Gde Bimananda Mahardika Wisna Jeongho Ha Chengyu Song Jin Zhang Sui Yang Xiang Zhang Zhaowei Liu Organic Hyperbolic Material Assisted Illumination Nanoscopy
description	Abstract Resolution capability of the linear structured illumination microscopy (SIM) plays a key role in its applications in physics, medicine, biology, and life science. Many advanced methodologies have been developed to extend the resolution of structured illumination by using subdiffraction‐limited optical excitation patterns. However, obtaining SIM images with a resolution beyond 40 nm at visible frequency remains as an insurmountable obstacle due to the intrinsic limitation of spatial frequency bandwidth of the involved materials and the complexity of the illumination system. Here, a low‐loss natural organic hyperbolic material (OHM) that can support record high spatial‐frequency modes beyond 50k0, i.e., effective refractive index larger than 50, at visible frequencies is reported. OHM‐based speckle structured illumination microscopy demonstrates imaging resolution at 30 nm scales with enhanced fluorophore photostability, biocompatibility, easy to use and low cost. This study will open up a new route in super‐resolution microscopy by utilizing OHM films for various applications including bioimaging and sensing.
format	article
author	Yeon Ui Lee Clara Posner Zhaoyu Nie Junxiang Zhao Shilong Li Steven Edward Bopp Gde Bimananda Mahardika Wisna Jeongho Ha Chengyu Song Jin Zhang Sui Yang Xiang Zhang Zhaowei Liu
author_facet	Yeon Ui Lee Clara Posner Zhaoyu Nie Junxiang Zhao Shilong Li Steven Edward Bopp Gde Bimananda Mahardika Wisna Jeongho Ha Chengyu Song Jin Zhang Sui Yang Xiang Zhang Zhaowei Liu
author_sort	Yeon Ui Lee
title	Organic Hyperbolic Material Assisted Illumination Nanoscopy
title_short	Organic Hyperbolic Material Assisted Illumination Nanoscopy
title_full	Organic Hyperbolic Material Assisted Illumination Nanoscopy
title_fullStr	Organic Hyperbolic Material Assisted Illumination Nanoscopy
title_full_unstemmed	Organic Hyperbolic Material Assisted Illumination Nanoscopy
title_sort	organic hyperbolic material assisted illumination nanoscopy
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/731b2c127898434ab79bed849954982d
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Organic Hyperbolic Material Assisted Illumination Nanoscopy

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