In Search of Model Ecological Systems for Understanding Specialized Metabolism

ABSTRACT Microbes occupy diverse habitats, forming interconnected, dynamic communities. Elucidating the principles of microbial community function is a grand challenge for microbiology, and it will entail experiments that engage microbiomes across multiple levels of complexity. For example, communit...

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Autores principales:	Rita C. Pessotti, Bridget L. Hansen, Matthew F. Traxler
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	chemical ecology interspecies interactions microbial ecology microbiome model systems specialized metabolism Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/731ed1845e0b4bc58b8a7968b0ea3601
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spelling	oai:doaj.org-article:731ed1845e0b4bc58b8a7968b0ea36012021-12-02T18:44:38ZIn Search of Model Ecological Systems for Understanding Specialized Metabolism10.1128/mSystems.00175-172379-5077https://doaj.org/article/731ed1845e0b4bc58b8a7968b0ea36012018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00175-17https://doaj.org/toc/2379-5077ABSTRACT Microbes occupy diverse habitats, forming interconnected, dynamic communities. Elucidating the principles of microbial community function is a grand challenge for microbiology, and it will entail experiments that engage microbiomes across multiple levels of complexity. For example, community-level hypotheses often require testing at the mechanistic and/or genetic levels, while mechanistic relationships require community-level evaluation to understand their importance in context. In this Perspective, we articulate the need for model microbiome systems that enable experimentation in both community and reductionist frameworks, with an emphasis on understanding the role of specialized metabolites in microbial communities. We consider essential criteria for developing such model microbiome systems and discuss potential future models that address the ecology of specialized metabolism.Rita C. PessottiBridget L. HansenMatthew F. TraxlerAmerican Society for Microbiologyarticlechemical ecologyinterspecies interactionsmicrobial ecologymicrobiomemodel systemsspecialized metabolismMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemical ecology interspecies interactions microbial ecology microbiome model systems specialized metabolism Microbiology QR1-502
spellingShingle	chemical ecology interspecies interactions microbial ecology microbiome model systems specialized metabolism Microbiology QR1-502 Rita C. Pessotti Bridget L. Hansen Matthew F. Traxler In Search of Model Ecological Systems for Understanding Specialized Metabolism
description	ABSTRACT Microbes occupy diverse habitats, forming interconnected, dynamic communities. Elucidating the principles of microbial community function is a grand challenge for microbiology, and it will entail experiments that engage microbiomes across multiple levels of complexity. For example, community-level hypotheses often require testing at the mechanistic and/or genetic levels, while mechanistic relationships require community-level evaluation to understand their importance in context. In this Perspective, we articulate the need for model microbiome systems that enable experimentation in both community and reductionist frameworks, with an emphasis on understanding the role of specialized metabolites in microbial communities. We consider essential criteria for developing such model microbiome systems and discuss potential future models that address the ecology of specialized metabolism.
format	article
author	Rita C. Pessotti Bridget L. Hansen Matthew F. Traxler
author_facet	Rita C. Pessotti Bridget L. Hansen Matthew F. Traxler
author_sort	Rita C. Pessotti
title	In Search of Model Ecological Systems for Understanding Specialized Metabolism
title_short	In Search of Model Ecological Systems for Understanding Specialized Metabolism
title_full	In Search of Model Ecological Systems for Understanding Specialized Metabolism
title_fullStr	In Search of Model Ecological Systems for Understanding Specialized Metabolism
title_full_unstemmed	In Search of Model Ecological Systems for Understanding Specialized Metabolism
title_sort	in search of model ecological systems for understanding specialized metabolism
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/731ed1845e0b4bc58b8a7968b0ea3601
work_keys_str_mv	AT ritacpessotti insearchofmodelecologicalsystemsforunderstandingspecializedmetabolism AT bridgetlhansen insearchofmodelecologicalsystemsforunderstandingspecializedmetabolism AT matthewftraxler insearchofmodelecologicalsystemsforunderstandingspecializedmetabolism
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In Search of Model Ecological Systems for Understanding Specialized Metabolism

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