Label-free X-ray estimation of brain amyloid burden

Abstract Amyloid plaque deposits in the brain are indicative of Alzheimer’s and other diseases. Measurements of brain amyloid burden in small animals require laborious post-mortem histological analysis or resource-intensive, contrast-enhanced imaging techniques. We describe a label-free method based...

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Autores principales:	Eshan Dahal, Bahaa Ghammraoui, Meijun Ye, J. Carson Smith, Aldo Badano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/731f3b49a1f043b8851d99b323918560
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spelling	oai:doaj.org-article:731f3b49a1f043b8851d99b3239185602021-12-02T15:10:18ZLabel-free X-ray estimation of brain amyloid burden10.1038/s41598-020-77554-52045-2322https://doaj.org/article/731f3b49a1f043b8851d99b3239185602020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77554-5https://doaj.org/toc/2045-2322Abstract Amyloid plaque deposits in the brain are indicative of Alzheimer’s and other diseases. Measurements of brain amyloid burden in small animals require laborious post-mortem histological analysis or resource-intensive, contrast-enhanced imaging techniques. We describe a label-free method based on spectral small-angle X-ray scattering with a polychromatic beam for in vivo estimation of brain amyloid burden. Our findings comparing 5XFAD versus wild-type mice correlate well with histology, showing promise for a fast and practical in vivo technique.Eshan DahalBahaa GhammraouiMeijun YeJ. Carson SmithAldo BadanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eshan Dahal Bahaa Ghammraoui Meijun Ye J. Carson Smith Aldo Badano Label-free X-ray estimation of brain amyloid burden
description	Abstract Amyloid plaque deposits in the brain are indicative of Alzheimer’s and other diseases. Measurements of brain amyloid burden in small animals require laborious post-mortem histological analysis or resource-intensive, contrast-enhanced imaging techniques. We describe a label-free method based on spectral small-angle X-ray scattering with a polychromatic beam for in vivo estimation of brain amyloid burden. Our findings comparing 5XFAD versus wild-type mice correlate well with histology, showing promise for a fast and practical in vivo technique.
format	article
author	Eshan Dahal Bahaa Ghammraoui Meijun Ye J. Carson Smith Aldo Badano
author_facet	Eshan Dahal Bahaa Ghammraoui Meijun Ye J. Carson Smith Aldo Badano
author_sort	Eshan Dahal
title	Label-free X-ray estimation of brain amyloid burden
title_short	Label-free X-ray estimation of brain amyloid burden
title_full	Label-free X-ray estimation of brain amyloid burden
title_fullStr	Label-free X-ray estimation of brain amyloid burden
title_full_unstemmed	Label-free X-ray estimation of brain amyloid burden
title_sort	label-free x-ray estimation of brain amyloid burden
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/731f3b49a1f043b8851d99b323918560
work_keys_str_mv	AT eshandahal labelfreexrayestimationofbrainamyloidburden AT bahaaghammraoui labelfreexrayestimationofbrainamyloidburden AT meijunye labelfreexrayestimationofbrainamyloidburden AT jcarsonsmith labelfreexrayestimationofbrainamyloidburden AT aldobadano labelfreexrayestimationofbrainamyloidburden
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Label-free X-ray estimation of brain amyloid burden

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