Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI

Purpose: Our purpose was to evaluate intra-prostatic cancer volumes for salvage radiotherapy in men with recurrent prostate cancer confined to the prostate post-primary radiotherapy using mpMRI and 18F-DCFPyL PET/CT (PET). Methods: Men with biochemical failure post-primary radiotherapy were enrolled...

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Autores principales:	Wei Liu, Hatim Fakir, Gurpreet Randhawa, Ryan Alfano, Mark Corkum, Zahra Kassam, Irina Rachinsky, Hans T. Chung, Peter Chung, Andrew Loblaw, Gerard Morton, Tracy Sexton, Anil Kapoor, Aaron Ward, Katherine Zukotynski, Louise Emmett, Glenn Bauman
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Prostate cancer PSMA PET/CT MRI Radio-recurrence Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/73250c64d9e24ee19ae41b44d5798e3d
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spelling	oai:doaj.org-article:73250c64d9e24ee19ae41b44d5798e3d2021-11-20T05:07:50ZDefining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI2405-630810.1016/j.ctro.2021.11.006https://doaj.org/article/73250c64d9e24ee19ae41b44d5798e3d2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405630821000975https://doaj.org/toc/2405-6308Purpose: Our purpose was to evaluate intra-prostatic cancer volumes for salvage radiotherapy in men with recurrent prostate cancer confined to the prostate post-primary radiotherapy using mpMRI and 18F-DCFPyL PET/CT (PET). Methods: Men with biochemical failure post-primary radiotherapy were enrolled in a multi-centre trial investigating mpMRI and PET. All men with isolated intra-prostatic recurrence are included in this secondary analysis. The intra-prostatic gross tumour volume (GTV) was manually delineated on mpMRI and was also delineated on PET using three methods: 1. manually, 2. using a 30% threshold of maximum intra-prostatic standard uptake value (SUVmax), and 3. using a 67% threshold of this SUVmax. Clinical target volumes (CTV) including expansions on each GTV were generated. Conformity indices were performed between the mpMRI CTV and each PET CTV. Correlation with biopsy and clinical outcomes were performed. Results: Of the 36 men included, 30 (83%) had disease in two quadrants or less using the combination of mpMRI and PET. Mean target volume (union of CTV on mpMRI and CTV manually delineated on PET) was 12.2 cc (49% of prostate gland volume). 12/36 (33%) men had a biopsy. Per-patient sensitivity was 91% for mpMRI and 82% for PET. Conclusions: mpMRI and PET provide complementary information for delineation of intra-prostatic recurrent disease. Union of CTV on mpMRI and PET is often less than 50% of the prostate, suggesting this imaging could help define a target for focal salvage therapy.Wei LiuHatim FakirGurpreet RandhawaRyan AlfanoMark CorkumZahra KassamIrina RachinskyHans T. ChungPeter ChungAndrew LoblawGerard MortonTracy SextonAnil KapoorAaron WardKatherine ZukotynskiLouise EmmettGlenn BaumanElsevierarticleProstate cancerPSMA PET/CTMRIRadio-recurrenceMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENClinical and Translational Radiation Oncology, Vol 32, Iss , Pp 41-47 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prostate cancer PSMA PET/CT MRI Radio-recurrence Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Prostate cancer PSMA PET/CT MRI Radio-recurrence Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wei Liu Hatim Fakir Gurpreet Randhawa Ryan Alfano Mark Corkum Zahra Kassam Irina Rachinsky Hans T. Chung Peter Chung Andrew Loblaw Gerard Morton Tracy Sexton Anil Kapoor Aaron Ward Katherine Zukotynski Louise Emmett Glenn Bauman Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
description	Purpose: Our purpose was to evaluate intra-prostatic cancer volumes for salvage radiotherapy in men with recurrent prostate cancer confined to the prostate post-primary radiotherapy using mpMRI and 18F-DCFPyL PET/CT (PET). Methods: Men with biochemical failure post-primary radiotherapy were enrolled in a multi-centre trial investigating mpMRI and PET. All men with isolated intra-prostatic recurrence are included in this secondary analysis. The intra-prostatic gross tumour volume (GTV) was manually delineated on mpMRI and was also delineated on PET using three methods: 1. manually, 2. using a 30% threshold of maximum intra-prostatic standard uptake value (SUVmax), and 3. using a 67% threshold of this SUVmax. Clinical target volumes (CTV) including expansions on each GTV were generated. Conformity indices were performed between the mpMRI CTV and each PET CTV. Correlation with biopsy and clinical outcomes were performed. Results: Of the 36 men included, 30 (83%) had disease in two quadrants or less using the combination of mpMRI and PET. Mean target volume (union of CTV on mpMRI and CTV manually delineated on PET) was 12.2 cc (49% of prostate gland volume). 12/36 (33%) men had a biopsy. Per-patient sensitivity was 91% for mpMRI and 82% for PET. Conclusions: mpMRI and PET provide complementary information for delineation of intra-prostatic recurrent disease. Union of CTV on mpMRI and PET is often less than 50% of the prostate, suggesting this imaging could help define a target for focal salvage therapy.
format	article
author	Wei Liu Hatim Fakir Gurpreet Randhawa Ryan Alfano Mark Corkum Zahra Kassam Irina Rachinsky Hans T. Chung Peter Chung Andrew Loblaw Gerard Morton Tracy Sexton Anil Kapoor Aaron Ward Katherine Zukotynski Louise Emmett Glenn Bauman
author_facet	Wei Liu Hatim Fakir Gurpreet Randhawa Ryan Alfano Mark Corkum Zahra Kassam Irina Rachinsky Hans T. Chung Peter Chung Andrew Loblaw Gerard Morton Tracy Sexton Anil Kapoor Aaron Ward Katherine Zukotynski Louise Emmett Glenn Bauman
author_sort	Wei Liu
title	Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
title_short	Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
title_full	Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
title_fullStr	Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
title_full_unstemmed	Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI
title_sort	defining radio-recurrent intra-prostatic target volumes using psma-targeted pet/ct and multi-parametric mri
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/73250c64d9e24ee19ae41b44d5798e3d
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Defining radio-recurrent intra-prostatic target volumes using PSMA-targeted PET/CT and multi-parametric MRI

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