A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor

A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated. It was based on the heterocyclization reactions of readily available electrophilic alkenes with the tetranitromethane-triethylamine complex. The structural di...

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Bibliographic Details
Main Authors: Dmitry A. Vasilenko, Kirill S. Sadovnikov, Kseniya N. Sedenkova, Dmitry S. Karlov, Eugene V. Radchenko, Yuri K. Grishin, Victor B. Rybakov, Tamara S. Kuznetsova, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, Elena B. Averina
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
heterocycles
medicinal chemistry
heterocyclization
tetranitromethane
isoxazole
bivalent ligand
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/732b363d7e634168a92b75b3ea43dab0
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https://doaj.org/article/732b363d7e634168a92b75b3ea43dab0

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