A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor

A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated. It was based on the heterocyclization reactions of readily available electrophilic alkenes with the tetranitromethane-triethylamine complex. The structural di...

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Auteurs principaux: Dmitry A. Vasilenko, Kirill S. Sadovnikov, Kseniya N. Sedenkova, Dmitry S. Karlov, Eugene V. Radchenko, Yuri K. Grishin, Victor B. Rybakov, Tamara S. Kuznetsova, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, Elena B. Averina
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
heterocycles
medicinal chemistry
heterocyclization
tetranitromethane
isoxazole
bivalent ligand
Organic chemistry
QD241-441
Accès en ligne:https://doaj.org/article/732b363d7e634168a92b75b3ea43dab0
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Internet

https://doaj.org/article/732b363d7e634168a92b75b3ea43dab0

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