Restoration of visual function by transplantation of optogenetically engineered photoreceptors

A challenge in cell therapy for photoreceptor degeneration is inducing the grafted cells to grow and maintain light sensitive outer segments. Here, the authors use optogenetics to circumvent this problem and restore visual function in blind mice.

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Autores principales:	Marcela Garita-Hernandez, Maruša Lampič, Antoine Chaffiol, Laure Guibbal, Fiona Routet, Tiago Santos-Ferreira, Sylvia Gasparini, Oliver Borsch, Giuliana Gagliardi, Sacha Reichman, Serge Picaud, José-Alain Sahel, Olivier Goureau, Marius Ader, Deniz Dalkara, Jens Duebel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/732d87294a534f1ab4fe044f1dcd7507
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spelling	oai:doaj.org-article:732d87294a534f1ab4fe044f1dcd75072021-12-02T14:38:42ZRestoration of visual function by transplantation of optogenetically engineered photoreceptors10.1038/s41467-019-12330-22041-1723https://doaj.org/article/732d87294a534f1ab4fe044f1dcd75072019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12330-2https://doaj.org/toc/2041-1723A challenge in cell therapy for photoreceptor degeneration is inducing the grafted cells to grow and maintain light sensitive outer segments. Here, the authors use optogenetics to circumvent this problem and restore visual function in blind mice.Marcela Garita-HernandezMaruša LampičAntoine ChaffiolLaure GuibbalFiona RoutetTiago Santos-FerreiraSylvia GaspariniOliver BorschGiuliana GagliardiSacha ReichmanSerge PicaudJosé-Alain SahelOlivier GoureauMarius AderDeniz DalkaraJens DuebelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marcela Garita-Hernandez Maruša Lampič Antoine Chaffiol Laure Guibbal Fiona Routet Tiago Santos-Ferreira Sylvia Gasparini Oliver Borsch Giuliana Gagliardi Sacha Reichman Serge Picaud José-Alain Sahel Olivier Goureau Marius Ader Deniz Dalkara Jens Duebel Restoration of visual function by transplantation of optogenetically engineered photoreceptors
description	A challenge in cell therapy for photoreceptor degeneration is inducing the grafted cells to grow and maintain light sensitive outer segments. Here, the authors use optogenetics to circumvent this problem and restore visual function in blind mice.
format	article
author	Marcela Garita-Hernandez Maruša Lampič Antoine Chaffiol Laure Guibbal Fiona Routet Tiago Santos-Ferreira Sylvia Gasparini Oliver Borsch Giuliana Gagliardi Sacha Reichman Serge Picaud José-Alain Sahel Olivier Goureau Marius Ader Deniz Dalkara Jens Duebel
author_facet	Marcela Garita-Hernandez Maruša Lampič Antoine Chaffiol Laure Guibbal Fiona Routet Tiago Santos-Ferreira Sylvia Gasparini Oliver Borsch Giuliana Gagliardi Sacha Reichman Serge Picaud José-Alain Sahel Olivier Goureau Marius Ader Deniz Dalkara Jens Duebel
author_sort	Marcela Garita-Hernandez
title	Restoration of visual function by transplantation of optogenetically engineered photoreceptors
title_short	Restoration of visual function by transplantation of optogenetically engineered photoreceptors
title_full	Restoration of visual function by transplantation of optogenetically engineered photoreceptors
title_fullStr	Restoration of visual function by transplantation of optogenetically engineered photoreceptors
title_full_unstemmed	Restoration of visual function by transplantation of optogenetically engineered photoreceptors
title_sort	restoration of visual function by transplantation of optogenetically engineered photoreceptors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/732d87294a534f1ab4fe044f1dcd7507
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Restoration of visual function by transplantation of optogenetically engineered photoreceptors

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