RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?

As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest even...

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Autores principales:	Samantha Lisy, Katherine Rothamel, Manuel Ascano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RNA binding proteins innate immunity viral infection host vs. pathogen post-transcriptional gene regulation RNA sensing Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/732d999924104d12a5a3b5fd6b1b3ac2
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id	oai:doaj.org-article:732d999924104d12a5a3b5fd6b1b3ac2
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spelling	oai:doaj.org-article:732d999924104d12a5a3b5fd6b1b3ac22021-11-25T19:13:02ZRNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?10.3390/v131121721999-4915https://doaj.org/article/732d999924104d12a5a3b5fd6b1b3ac22021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2172https://doaj.org/toc/1999-4915As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest events between viral RNA and the RBPs that act upon them. These discoveries have sparked a re-evaluation of current paradigms surrounding RBPs and post-transcriptional gene regulation. Here, we highlight questions that have bloomed from the implementation of these novel approaches. Canonical RBPs can impact the fates of both cellular and viral RNA during infection, sometimes in conflicting ways. Noncanonical RBPs, some of which were first characterized via interactions with viral RNA, may encompass physiological roles beyond viral pathogenesis. We discuss how these RBPs might discriminate between an RNA of either cellular or viral origin and thus exert either pro- or antiviral effects—which is a particular challenge as viruses contain mechanisms to mimic molecular features of cellular RNA.Samantha LisyKatherine RothamelManuel AscanoMDPI AGarticleRNA binding proteinsinnate immunityviral infectionhost vs. pathogenpost-transcriptional gene regulationRNA sensingMicrobiologyQR1-502ENViruses, Vol 13, Iss 2172, p 2172 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RNA binding proteins innate immunity viral infection host vs. pathogen post-transcriptional gene regulation RNA sensing Microbiology QR1-502
spellingShingle	RNA binding proteins innate immunity viral infection host vs. pathogen post-transcriptional gene regulation RNA sensing Microbiology QR1-502 Samantha Lisy Katherine Rothamel Manuel Ascano RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
description	As the first intracellular host factors that directly interact with the genomes of RNA viruses, RNA binding proteins (RBPs) have a profound impact on the outcome of an infection. Recent discoveries brought about by new methodologies have led to an unprecedented ability to peer into the earliest events between viral RNA and the RBPs that act upon them. These discoveries have sparked a re-evaluation of current paradigms surrounding RBPs and post-transcriptional gene regulation. Here, we highlight questions that have bloomed from the implementation of these novel approaches. Canonical RBPs can impact the fates of both cellular and viral RNA during infection, sometimes in conflicting ways. Noncanonical RBPs, some of which were first characterized via interactions with viral RNA, may encompass physiological roles beyond viral pathogenesis. We discuss how these RBPs might discriminate between an RNA of either cellular or viral origin and thus exert either pro- or antiviral effects—which is a particular challenge as viruses contain mechanisms to mimic molecular features of cellular RNA.
format	article
author	Samantha Lisy Katherine Rothamel Manuel Ascano
author_facet	Samantha Lisy Katherine Rothamel Manuel Ascano
author_sort	Samantha Lisy
title	RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
title_short	RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
title_full	RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
title_fullStr	RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
title_full_unstemmed	RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?
title_sort	rna binding proteins as pioneer determinants of infection: protective, proviral, or both?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/732d999924104d12a5a3b5fd6b1b3ac2
work_keys_str_mv	AT samanthalisy rnabindingproteinsaspioneerdeterminantsofinfectionprotectiveproviralorboth AT katherinerothamel rnabindingproteinsaspioneerdeterminantsofinfectionprotectiveproviralorboth AT manuelascano rnabindingproteinsaspioneerdeterminantsofinfectionprotectiveproviralorboth
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RNA Binding Proteins as Pioneer Determinants of Infection: Protective, Proviral, or Both?

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