STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

Innate immune signaling pathways sense different microbial features and can elicit distinct yet overlapping immune responses. Here the authors dissect the contribution of these pathways to the response to MCMV infection and find that STING signaling is dispensable for host survival but crucial to re...

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Autores principales: Pia-Katharina Tegtmeyer, Julia Spanier, Katharina Borst, Jennifer Becker, André Riedl, Christoph Hirche, Luca Ghita, Jennifer Skerra, Kira Baumann, Stefan Lienenklaus, Marius Doering, Zsolt Ruzsics, Ulrich Kalinke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/732e3457c28042c99ed0e7ef5475e565
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spelling oai:doaj.org-article:732e3457c28042c99ed0e7ef5475e5652021-12-02T17:32:08ZSTING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus10.1038/s41467-019-10863-02041-1723https://doaj.org/article/732e3457c28042c99ed0e7ef5475e5652019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10863-0https://doaj.org/toc/2041-1723Innate immune signaling pathways sense different microbial features and can elicit distinct yet overlapping immune responses. Here the authors dissect the contribution of these pathways to the response to MCMV infection and find that STING signaling is dispensable for host survival but crucial to restrict viral replication and dissemination via myeloid cells.Pia-Katharina TegtmeyerJulia SpanierKatharina BorstJennifer BeckerAndré RiedlChristoph HircheLuca GhitaJennifer SkerraKira BaumannStefan LienenklausMarius DoeringZsolt RuzsicsUlrich KalinkeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pia-Katharina Tegtmeyer
Julia Spanier
Katharina Borst
Jennifer Becker
André Riedl
Christoph Hirche
Luca Ghita
Jennifer Skerra
Kira Baumann
Stefan Lienenklaus
Marius Doering
Zsolt Ruzsics
Ulrich Kalinke
STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
description Innate immune signaling pathways sense different microbial features and can elicit distinct yet overlapping immune responses. Here the authors dissect the contribution of these pathways to the response to MCMV infection and find that STING signaling is dispensable for host survival but crucial to restrict viral replication and dissemination via myeloid cells.
format article
author Pia-Katharina Tegtmeyer
Julia Spanier
Katharina Borst
Jennifer Becker
André Riedl
Christoph Hirche
Luca Ghita
Jennifer Skerra
Kira Baumann
Stefan Lienenklaus
Marius Doering
Zsolt Ruzsics
Ulrich Kalinke
author_facet Pia-Katharina Tegtmeyer
Julia Spanier
Katharina Borst
Jennifer Becker
André Riedl
Christoph Hirche
Luca Ghita
Jennifer Skerra
Kira Baumann
Stefan Lienenklaus
Marius Doering
Zsolt Ruzsics
Ulrich Kalinke
author_sort Pia-Katharina Tegtmeyer
title STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_short STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_full STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_fullStr STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_full_unstemmed STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_sort sting induces early ifn-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/732e3457c28042c99ed0e7ef5475e565
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