STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

Innate immune signaling pathways sense different microbial features and can elicit distinct yet overlapping immune responses. Here the authors dissect the contribution of these pathways to the response to MCMV infection and find that STING signaling is dispensable for host survival but crucial to re...

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Auteurs principaux:	Pia-Katharina Tegtmeyer, Julia Spanier, Katharina Borst, Jennifer Becker, André Riedl, Christoph Hirche, Luca Ghita, Jennifer Skerra, Kira Baumann, Stefan Lienenklaus, Marius Doering, Zsolt Ruzsics, Ulrich Kalinke
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/732e3457c28042c99ed0e7ef5475e565
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spelling	oai:doaj.org-article:732e3457c28042c99ed0e7ef5475e5652021-12-02T17:32:08ZSTING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus10.1038/s41467-019-10863-02041-1723https://doaj.org/article/732e3457c28042c99ed0e7ef5475e5652019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10863-0https://doaj.org/toc/2041-1723Innate immune signaling pathways sense different microbial features and can elicit distinct yet overlapping immune responses. Here the authors dissect the contribution of these pathways to the response to MCMV infection and find that STING signaling is dispensable for host survival but crucial to restrict viral replication and dissemination via myeloid cells.Pia-Katharina TegtmeyerJulia SpanierKatharina BorstJennifer BeckerAndré RiedlChristoph HircheLuca GhitaJennifer SkerraKira BaumannStefan LienenklausMarius DoeringZsolt RuzsicsUlrich KalinkeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pia-Katharina Tegtmeyer Julia Spanier Katharina Borst Jennifer Becker André Riedl Christoph Hirche Luca Ghita Jennifer Skerra Kira Baumann Stefan Lienenklaus Marius Doering Zsolt Ruzsics Ulrich Kalinke STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
description	Innate immune signaling pathways sense different microbial features and can elicit distinct yet overlapping immune responses. Here the authors dissect the contribution of these pathways to the response to MCMV infection and find that STING signaling is dispensable for host survival but crucial to restrict viral replication and dissemination via myeloid cells.
format	article
author	Pia-Katharina Tegtmeyer Julia Spanier Katharina Borst Jennifer Becker André Riedl Christoph Hirche Luca Ghita Jennifer Skerra Kira Baumann Stefan Lienenklaus Marius Doering Zsolt Ruzsics Ulrich Kalinke
author_facet	Pia-Katharina Tegtmeyer Julia Spanier Katharina Borst Jennifer Becker André Riedl Christoph Hirche Luca Ghita Jennifer Skerra Kira Baumann Stefan Lienenklaus Marius Doering Zsolt Ruzsics Ulrich Kalinke
author_sort	Pia-Katharina Tegtmeyer
title	STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_short	STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_full	STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_fullStr	STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_full_unstemmed	STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
title_sort	sting induces early ifn-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/732e3457c28042c99ed0e7ef5475e565
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STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

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