Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach

Abstract Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of immunochemokines compared to multiportal VATS have...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peter S. Y. Yu, Kin Wai Chan, Rainbow W. H. Lau, Innes Y. P. Wan, George G. Chen, Calvin S. H. Ng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7330289d71f84833be0351e0dd0aec20
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7330289d71f84833be0351e0dd0aec20
record_format	dspace
spelling	oai:doaj.org-article:7330289d71f84833be0351e0dd0aec202021-12-02T17:16:05ZUniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach10.1038/s41598-021-89598-22045-2322https://doaj.org/article/7330289d71f84833be0351e0dd0aec202021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89598-2https://doaj.org/toc/2045-2322Abstract Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of immunochemokines compared to multiportal VATS have not been studied. Selected patients who received uniportal or multiportal VATS major lung resection were recruited. Blood samples were collected preoperatively and on postoperative days 1 and 3 for enzyme linked immunosorbent assay of serum levels of Tissue Inhibitor of Metalloproteinase (TIMP)-1, Insulin Growth Factor Binding Protein (IGFBP)-3, and Matrix Metalloproteinase (MMP)-9. A linear mixed-effects models were used to analyze the effects of uniportal VATS on the postoperative circulating chemokine levels. From March 2014 to April 2017, 68 consecutive patients consented for the prospective study and received major lung resection by either uniportal VATS (N = 29) or multiportal VATS (N = 39) were identified. Uniportal VATS major lung resection was associated with lower post-operative levels of TIMP-1 and MMP-9 compared to multiportal VATS after controlling for the effects of the corresponding baseline level and the time of follow-up measurement. No difference was observed for the level of IGFBP-3. Less immunochemokine disturbances was observed after uniportal VATS major lung resection compared to multiportal VATS.Peter S. Y. YuKin Wai ChanRainbow W. H. LauInnes Y. P. WanGeorge G. ChenCalvin S. H. NgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter S. Y. Yu Kin Wai Chan Rainbow W. H. Lau Innes Y. P. Wan George G. Chen Calvin S. H. Ng Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach
description	Abstract Multiportal video-assisted thoracic surgery (VATS) for major lung resection causes less immunochemokine production compared to thoracotomy. Whether uniportal VATS is similarly associated with lower early postoperative circulating levels of immunochemokines compared to multiportal VATS have not been studied. Selected patients who received uniportal or multiportal VATS major lung resection were recruited. Blood samples were collected preoperatively and on postoperative days 1 and 3 for enzyme linked immunosorbent assay of serum levels of Tissue Inhibitor of Metalloproteinase (TIMP)-1, Insulin Growth Factor Binding Protein (IGFBP)-3, and Matrix Metalloproteinase (MMP)-9. A linear mixed-effects models were used to analyze the effects of uniportal VATS on the postoperative circulating chemokine levels. From March 2014 to April 2017, 68 consecutive patients consented for the prospective study and received major lung resection by either uniportal VATS (N = 29) or multiportal VATS (N = 39) were identified. Uniportal VATS major lung resection was associated with lower post-operative levels of TIMP-1 and MMP-9 compared to multiportal VATS after controlling for the effects of the corresponding baseline level and the time of follow-up measurement. No difference was observed for the level of IGFBP-3. Less immunochemokine disturbances was observed after uniportal VATS major lung resection compared to multiportal VATS.
format	article
author	Peter S. Y. Yu Kin Wai Chan Rainbow W. H. Lau Innes Y. P. Wan George G. Chen Calvin S. H. Ng
author_facet	Peter S. Y. Yu Kin Wai Chan Rainbow W. H. Lau Innes Y. P. Wan George G. Chen Calvin S. H. Ng
author_sort	Peter S. Y. Yu
title	Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach
title_short	Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach
title_full	Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach
title_fullStr	Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach
title_full_unstemmed	Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach
title_sort	uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7330289d71f84833be0351e0dd0aec20
work_keys_str_mv	AT petersyyu uniportalvideoassistedthoracicsurgeryformajorlungresectionisassociatedwithlessimmunochemokinedisturbancesthanmultiportalapproach AT kinwaichan uniportalvideoassistedthoracicsurgeryformajorlungresectionisassociatedwithlessimmunochemokinedisturbancesthanmultiportalapproach AT rainbowwhlau uniportalvideoassistedthoracicsurgeryformajorlungresectionisassociatedwithlessimmunochemokinedisturbancesthanmultiportalapproach AT innesypwan uniportalvideoassistedthoracicsurgeryformajorlungresectionisassociatedwithlessimmunochemokinedisturbancesthanmultiportalapproach AT georgegchen uniportalvideoassistedthoracicsurgeryformajorlungresectionisassociatedwithlessimmunochemokinedisturbancesthanmultiportalapproach AT calvinshng uniportalvideoassistedthoracicsurgeryformajorlungresectionisassociatedwithlessimmunochemokinedisturbancesthanmultiportalapproach
_version_	1718381205905211392

Uniportal video-assisted thoracic surgery for major lung resection is associated with less immunochemokine disturbances than multiportal approach

Ejemplares similares