Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India

Abstract Bacterial antibiotic resistance is an important global health threat and the interfaces of antibiotic resistance between humans, animals and the environment are complex. We aimed to determine the associations and overtime trends of antibiotic resistance between humans, animals and water sou...

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Autores principales:	Joseph Mitchell, Manju Purohit, Chris P. Jewell, Jonathan M. Read, Gaetano Marrone, Vishal Diwan, Cecilia Stålsby Lundborg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7331094b886f4ede9f6fde2251bebed7
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spelling	oai:doaj.org-article:7331094b886f4ede9f6fde2251bebed72021-11-21T12:19:36ZTrends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India10.1038/s41598-021-01174-w2045-2322https://doaj.org/article/7331094b886f4ede9f6fde2251bebed72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01174-whttps://doaj.org/toc/2045-2322Abstract Bacterial antibiotic resistance is an important global health threat and the interfaces of antibiotic resistance between humans, animals and the environment are complex. We aimed to determine the associations and overtime trends of antibiotic resistance between humans, animals and water sources from the same area and time and estimate attribution of the other sources to cases of human antibiotic resistance. A total of 125 children (aged 1–3 years old) had stool samples analysed for antibiotic-resistant bacteria at seven time points over two years, with simultaneous collection of samples of animal stools and water sources in a rural Indian community. Newey–West regression models were used to calculate temporal associations, the source with the most statistically significant relationships was household drinking water. This is supported by use of SourceR attribution modelling, that estimated the mean attribution of cases of antibiotic resistance in the children from animals, household drinking water and wastewater, at each time point and location, to be 12.6% (95% CI 4.4–20.9%), 12.1% (CI 3.4–20.7%) and 10.3% (CI 3.2–17.3%) respectively. This underlines the importance of the ‘one health’ concept and requires further research. Also, most of the significant trends over time were negative, suggesting a possible generalised improvement locally.Joseph MitchellManju PurohitChris P. JewellJonathan M. ReadGaetano MarroneVishal DiwanCecilia Stålsby LundborgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph Mitchell Manju Purohit Chris P. Jewell Jonathan M. Read Gaetano Marrone Vishal Diwan Cecilia Stålsby Lundborg Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India
description	Abstract Bacterial antibiotic resistance is an important global health threat and the interfaces of antibiotic resistance between humans, animals and the environment are complex. We aimed to determine the associations and overtime trends of antibiotic resistance between humans, animals and water sources from the same area and time and estimate attribution of the other sources to cases of human antibiotic resistance. A total of 125 children (aged 1–3 years old) had stool samples analysed for antibiotic-resistant bacteria at seven time points over two years, with simultaneous collection of samples of animal stools and water sources in a rural Indian community. Newey–West regression models were used to calculate temporal associations, the source with the most statistically significant relationships was household drinking water. This is supported by use of SourceR attribution modelling, that estimated the mean attribution of cases of antibiotic resistance in the children from animals, household drinking water and wastewater, at each time point and location, to be 12.6% (95% CI 4.4–20.9%), 12.1% (CI 3.4–20.7%) and 10.3% (CI 3.2–17.3%) respectively. This underlines the importance of the ‘one health’ concept and requires further research. Also, most of the significant trends over time were negative, suggesting a possible generalised improvement locally.
format	article
author	Joseph Mitchell Manju Purohit Chris P. Jewell Jonathan M. Read Gaetano Marrone Vishal Diwan Cecilia Stålsby Lundborg
author_facet	Joseph Mitchell Manju Purohit Chris P. Jewell Jonathan M. Read Gaetano Marrone Vishal Diwan Cecilia Stålsby Lundborg
author_sort	Joseph Mitchell
title	Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India
title_short	Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India
title_full	Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India
title_fullStr	Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India
title_full_unstemmed	Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India
title_sort	trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural india
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7331094b886f4ede9f6fde2251bebed7
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Trends, relationships and case attribution of antibiotic resistance between children and environmental sources in rural India

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