Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog

Abstract The neural correlates of spaceflight-induced sensorimotor impairments are unknown. Head down-tilt bed rest (HDBR) serves as a microgravity analog because it mimics the headward fluid shift and axial body unloading of spaceflight. We investigated focal brain white matter (WM) changes and flu...

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Autores principales:	Vincent Koppelmans, Ofer Pasternak, Jacob J. Bloomberg, Yiri E. De Dios, Scott J. Wood, Roy Riascos, Patricia A. Reuter-Lorenz, Igor S. Kofman, Ajitkumar P. Mulavara, Rachael D. Seidler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7334f3cf80f84e17981fff3d6253a974
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spelling	oai:doaj.org-article:7334f3cf80f84e17981fff3d6253a9742021-12-02T12:32:12ZIntracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog10.1038/s41598-017-03311-w2045-2322https://doaj.org/article/7334f3cf80f84e17981fff3d6253a9742017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03311-whttps://doaj.org/toc/2045-2322Abstract The neural correlates of spaceflight-induced sensorimotor impairments are unknown. Head down-tilt bed rest (HDBR) serves as a microgravity analog because it mimics the headward fluid shift and axial body unloading of spaceflight. We investigated focal brain white matter (WM) changes and fluid shifts during 70 days of 6° HDBR in 16 subjects who were assessed pre (2x), during (3x), and post-HDBR (2x). Changes over time were compared to those in control subjects (n = 12) assessed four times over 90 days. Diffusion MRI was used to assess WM microstructure and fluid shifts. Free-Water Imaging was used to quantify distribution of intracranial extracellular free water (FW). Additionally, we tested whether WM and FW changes correlated with changes in functional mobility and balance measures. HDBR resulted in FW increases in fronto-temporal regions and decreases in posterior-parietal regions that largely recovered by two weeks post-HDBR. WM microstructure was unaffected by HDBR. FW decreases in the post-central gyrus and precuneus correlated negatively with balance changes. We previously reported that gray matter increases in these regions were associated with less HDBR-induced balance impairment, suggesting adaptive structural neuroplasticity. Future studies are warranted to determine causality and underlying mechanisms.Vincent KoppelmansOfer PasternakJacob J. BloombergYiri E. De DiosScott J. WoodRoy RiascosPatricia A. Reuter-LorenzIgor S. KofmanAjitkumar P. MulavaraRachael D. SeidlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vincent Koppelmans Ofer Pasternak Jacob J. Bloomberg Yiri E. De Dios Scott J. Wood Roy Riascos Patricia A. Reuter-Lorenz Igor S. Kofman Ajitkumar P. Mulavara Rachael D. Seidler Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog
description	Abstract The neural correlates of spaceflight-induced sensorimotor impairments are unknown. Head down-tilt bed rest (HDBR) serves as a microgravity analog because it mimics the headward fluid shift and axial body unloading of spaceflight. We investigated focal brain white matter (WM) changes and fluid shifts during 70 days of 6° HDBR in 16 subjects who were assessed pre (2x), during (3x), and post-HDBR (2x). Changes over time were compared to those in control subjects (n = 12) assessed four times over 90 days. Diffusion MRI was used to assess WM microstructure and fluid shifts. Free-Water Imaging was used to quantify distribution of intracranial extracellular free water (FW). Additionally, we tested whether WM and FW changes correlated with changes in functional mobility and balance measures. HDBR resulted in FW increases in fronto-temporal regions and decreases in posterior-parietal regions that largely recovered by two weeks post-HDBR. WM microstructure was unaffected by HDBR. FW decreases in the post-central gyrus and precuneus correlated negatively with balance changes. We previously reported that gray matter increases in these regions were associated with less HDBR-induced balance impairment, suggesting adaptive structural neuroplasticity. Future studies are warranted to determine causality and underlying mechanisms.
format	article
author	Vincent Koppelmans Ofer Pasternak Jacob J. Bloomberg Yiri E. De Dios Scott J. Wood Roy Riascos Patricia A. Reuter-Lorenz Igor S. Kofman Ajitkumar P. Mulavara Rachael D. Seidler
author_facet	Vincent Koppelmans Ofer Pasternak Jacob J. Bloomberg Yiri E. De Dios Scott J. Wood Roy Riascos Patricia A. Reuter-Lorenz Igor S. Kofman Ajitkumar P. Mulavara Rachael D. Seidler
author_sort	Vincent Koppelmans
title	Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog
title_short	Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog
title_full	Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog
title_fullStr	Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog
title_full_unstemmed	Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog
title_sort	intracranial fluid redistribution but no white matter microstructural changes during a spaceflight analog
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7334f3cf80f84e17981fff3d6253a974
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Intracranial Fluid Redistribution But No White Matter Microstructural Changes During a Spaceflight Analog

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