Predictive factors of venous recanalization in upper-extremity vein thrombosis.
<h4>Background</h4>Upper extremity venous thrombosis (UEVT) represents about 10% of venous thrombo-embolic disease. This is mainly explained by the increasing use of central venous line, for oncologic or nutritional care. The factors associated with venous recanalization are not known.&l...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7335f2764ea542d48cb392dbd0f57768 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7335f2764ea542d48cb392dbd0f57768 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7335f2764ea542d48cb392dbd0f577682021-12-02T20:05:37ZPredictive factors of venous recanalization in upper-extremity vein thrombosis.1932-620310.1371/journal.pone.0251269https://doaj.org/article/7335f2764ea542d48cb392dbd0f577682021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251269https://doaj.org/toc/1932-6203<h4>Background</h4>Upper extremity venous thrombosis (UEVT) represents about 10% of venous thrombo-embolic disease. This is mainly explained by the increasing use of central venous line, for oncologic or nutritional care. The factors associated with venous recanalization are not known.<h4>Objective</h4>The aim of this study was to investigate prognosis factor associated with venous recanalization after UEVT.<h4>Methods</h4>This study included patients with UEVT diagnosed with duplex ultra-sonography (DUS) from January 2015 to December 2017 with DUS evaluations during follow-up. A multivariate Cox proportional-hazards-model analysis was performed to identify predictive factors of UEVT complete recanalization.<h4>Results</h4>This study included 494 UEVT, 304 proximal UEVT and 190 distal UEVT. The median age was 58 years, 39.5% were women. Clinical context was: hematological malignancy (40.7%), solid cancer (14.2%), infectious or inflammatory context (49.9%) and presence of venous catheters or pacemaker leads in 86.4%. The rate of recanalization without sequelae of UEVT was 38%. For all UEVT, in multivariate analysis, factors associated with complete vein recanalization were: thrombosis associated with central venous catheter (CVC) (HR:2.40, [1.45;3.95], p<0.001), UEVT limited to a venous segment (HR:1.94, [1.26;3.00], p = 0.003), occlusive thrombosis (HR:0.48 [0.34;0.67], p<0.0001), the presence of a PICC Line (HR:2.29, [1.48;3.52], p<0.001), a thrombosis of deep and distal topography (HR:1.70, [1.10;2.63], p = 0.02) or superficial thrombosis of the forearm (HR:2.79, [1.52;5.12], p<0.001). For deep and proximal UEVT, non-occlusive UEVT (HR:2.23, [1.49;3.33], p<0.0001), thrombosis associated with CVC (HR:1.58, [1.01;2.47], p = 0.04) and infectious or inflammatory context (HR:1.63, [1.10;2.41], p = 0.01) were factors associated with complete vein recanalization.<h4>Conclusion</h4>In this study, factors associated with UEVT recanalization were UEVT limited to a venous segment, thrombosis associated with CVC, a thrombosis of deep and distal thrombosis topography and superficial thrombosis of the forearm. Occlusive thrombosis was associated with the absence of UEVT recanalization.Gaëtan PlotonNicolas BrebionBéatrice GuyomarchMarc-Antoine PistoriusJérôme ConnaultJeanne HersantAlizée RaimbeauGuillaume BergèreMathieu ArtifoniCécile DurantGiovanni GautierRomain DumontJean-Manuel KubinaClaire ToquetOlivier EspitiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251269 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Gaëtan Ploton Nicolas Brebion Béatrice Guyomarch Marc-Antoine Pistorius Jérôme Connault Jeanne Hersant Alizée Raimbeau Guillaume Bergère Mathieu Artifoni Cécile Durant Giovanni Gautier Romain Dumont Jean-Manuel Kubina Claire Toquet Olivier Espitia Predictive factors of venous recanalization in upper-extremity vein thrombosis. |
| description |
<h4>Background</h4>Upper extremity venous thrombosis (UEVT) represents about 10% of venous thrombo-embolic disease. This is mainly explained by the increasing use of central venous line, for oncologic or nutritional care. The factors associated with venous recanalization are not known.<h4>Objective</h4>The aim of this study was to investigate prognosis factor associated with venous recanalization after UEVT.<h4>Methods</h4>This study included patients with UEVT diagnosed with duplex ultra-sonography (DUS) from January 2015 to December 2017 with DUS evaluations during follow-up. A multivariate Cox proportional-hazards-model analysis was performed to identify predictive factors of UEVT complete recanalization.<h4>Results</h4>This study included 494 UEVT, 304 proximal UEVT and 190 distal UEVT. The median age was 58 years, 39.5% were women. Clinical context was: hematological malignancy (40.7%), solid cancer (14.2%), infectious or inflammatory context (49.9%) and presence of venous catheters or pacemaker leads in 86.4%. The rate of recanalization without sequelae of UEVT was 38%. For all UEVT, in multivariate analysis, factors associated with complete vein recanalization were: thrombosis associated with central venous catheter (CVC) (HR:2.40, [1.45;3.95], p<0.001), UEVT limited to a venous segment (HR:1.94, [1.26;3.00], p = 0.003), occlusive thrombosis (HR:0.48 [0.34;0.67], p<0.0001), the presence of a PICC Line (HR:2.29, [1.48;3.52], p<0.001), a thrombosis of deep and distal topography (HR:1.70, [1.10;2.63], p = 0.02) or superficial thrombosis of the forearm (HR:2.79, [1.52;5.12], p<0.001). For deep and proximal UEVT, non-occlusive UEVT (HR:2.23, [1.49;3.33], p<0.0001), thrombosis associated with CVC (HR:1.58, [1.01;2.47], p = 0.04) and infectious or inflammatory context (HR:1.63, [1.10;2.41], p = 0.01) were factors associated with complete vein recanalization.<h4>Conclusion</h4>In this study, factors associated with UEVT recanalization were UEVT limited to a venous segment, thrombosis associated with CVC, a thrombosis of deep and distal thrombosis topography and superficial thrombosis of the forearm. Occlusive thrombosis was associated with the absence of UEVT recanalization. |
| format |
article |
| author |
Gaëtan Ploton Nicolas Brebion Béatrice Guyomarch Marc-Antoine Pistorius Jérôme Connault Jeanne Hersant Alizée Raimbeau Guillaume Bergère Mathieu Artifoni Cécile Durant Giovanni Gautier Romain Dumont Jean-Manuel Kubina Claire Toquet Olivier Espitia |
| author_facet |
Gaëtan Ploton Nicolas Brebion Béatrice Guyomarch Marc-Antoine Pistorius Jérôme Connault Jeanne Hersant Alizée Raimbeau Guillaume Bergère Mathieu Artifoni Cécile Durant Giovanni Gautier Romain Dumont Jean-Manuel Kubina Claire Toquet Olivier Espitia |
| author_sort |
Gaëtan Ploton |
| title |
Predictive factors of venous recanalization in upper-extremity vein thrombosis. |
| title_short |
Predictive factors of venous recanalization in upper-extremity vein thrombosis. |
| title_full |
Predictive factors of venous recanalization in upper-extremity vein thrombosis. |
| title_fullStr |
Predictive factors of venous recanalization in upper-extremity vein thrombosis. |
| title_full_unstemmed |
Predictive factors of venous recanalization in upper-extremity vein thrombosis. |
| title_sort |
predictive factors of venous recanalization in upper-extremity vein thrombosis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/7335f2764ea542d48cb392dbd0f57768 |
| work_keys_str_mv |
AT gaetanploton predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT nicolasbrebion predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT beatriceguyomarch predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT marcantoinepistorius predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT jeromeconnault predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT jeannehersant predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT alizeeraimbeau predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT guillaumebergere predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT mathieuartifoni predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT ceciledurant predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT giovannigautier predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT romaindumont predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT jeanmanuelkubina predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT clairetoquet predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis AT olivierespitia predictivefactorsofvenousrecanalizationinupperextremityveinthrombosis |
| _version_ |
1718375432741453824 |