Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S

Endoglycosidase S only recognizes one particular type of glycan within IgG antibodies but the molecular basis for this high specificity is not fully understood. Here, the authors present the crystal structure of product-bound Endoglycosidase S, revealing the determinants for its glycan specificity.

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Autores principales:	Beatriz Trastoy, Erik Klontz, Jared Orwenyo, Alberto Marina, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/733a7aaf8d0e4ff182ca5cc6f40ca189
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spelling	oai:doaj.org-article:733a7aaf8d0e4ff182ca5cc6f40ca1892021-12-02T15:33:41ZStructural basis for the recognition of complex-type N-glycans by Endoglycosidase S10.1038/s41467-018-04300-x2041-1723https://doaj.org/article/733a7aaf8d0e4ff182ca5cc6f40ca1892018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04300-xhttps://doaj.org/toc/2041-1723Endoglycosidase S only recognizes one particular type of glycan within IgG antibodies but the molecular basis for this high specificity is not fully understood. Here, the authors present the crystal structure of product-bound Endoglycosidase S, revealing the determinants for its glycan specificity.Beatriz TrastoyErik KlontzJared OrwenyoAlberto MarinaLai-Xi WangEric J. SundbergMarcelo E. GuerinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Beatriz Trastoy Erik Klontz Jared Orwenyo Alberto Marina Lai-Xi Wang Eric J. Sundberg Marcelo E. Guerin Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S
description	Endoglycosidase S only recognizes one particular type of glycan within IgG antibodies but the molecular basis for this high specificity is not fully understood. Here, the authors present the crystal structure of product-bound Endoglycosidase S, revealing the determinants for its glycan specificity.
format	article
author	Beatriz Trastoy Erik Klontz Jared Orwenyo Alberto Marina Lai-Xi Wang Eric J. Sundberg Marcelo E. Guerin
author_facet	Beatriz Trastoy Erik Klontz Jared Orwenyo Alberto Marina Lai-Xi Wang Eric J. Sundberg Marcelo E. Guerin
author_sort	Beatriz Trastoy
title	Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S
title_short	Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S
title_full	Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S
title_fullStr	Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S
title_full_unstemmed	Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S
title_sort	structural basis for the recognition of complex-type n-glycans by endoglycosidase s
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/733a7aaf8d0e4ff182ca5cc6f40ca189
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Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S

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