Pathway-targeting gene matrix for Drosophila gene set enrichment analysis

Gene Set Enrichment Analysis (GSEA) is a powerful algorithm to determine biased pathways between groups based on expression profiling. However, for fruit fly, a popular animal model, gene matrixes for GSEA are unavailable. This study provides the pathway-targeting gene matrixes based on Reactome and...

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Autores principales:	Jack Cheng, Lee-Fen Hsu, Ying-Hsu Juan, Hsin-Ping Liu, Wei-Yong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/733dcd8cdd1b4f8181bda0cfdeeb0b9f
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spelling	oai:doaj.org-article:733dcd8cdd1b4f8181bda0cfdeeb0b9f2021-11-04T06:49:32ZPathway-targeting gene matrix for Drosophila gene set enrichment analysis1932-6203https://doaj.org/article/733dcd8cdd1b4f8181bda0cfdeeb0b9f2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553153/?tool=EBIhttps://doaj.org/toc/1932-6203Gene Set Enrichment Analysis (GSEA) is a powerful algorithm to determine biased pathways between groups based on expression profiling. However, for fruit fly, a popular animal model, gene matrixes for GSEA are unavailable. This study provides the pathway-targeting gene matrixes based on Reactome and KEGG database for fruit fly. An expression profiling containing neurons or glia of fruit fly was used to validate the feasibility of the generated gene matrixes. We validated the gene matrixes and identified characteristic neuronal and glial pathways, including mRNA splicing and endocytosis. In conclusion, we generated and validated the feasibility of Reactome and KEGG gene matrix files, which may benefit future profiling studies using Drosophila.Jack ChengLee-Fen HsuYing-Hsu JuanHsin-Ping LiuWei-Yong LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jack Cheng Lee-Fen Hsu Ying-Hsu Juan Hsin-Ping Liu Wei-Yong Lin Pathway-targeting gene matrix for Drosophila gene set enrichment analysis
description	Gene Set Enrichment Analysis (GSEA) is a powerful algorithm to determine biased pathways between groups based on expression profiling. However, for fruit fly, a popular animal model, gene matrixes for GSEA are unavailable. This study provides the pathway-targeting gene matrixes based on Reactome and KEGG database for fruit fly. An expression profiling containing neurons or glia of fruit fly was used to validate the feasibility of the generated gene matrixes. We validated the gene matrixes and identified characteristic neuronal and glial pathways, including mRNA splicing and endocytosis. In conclusion, we generated and validated the feasibility of Reactome and KEGG gene matrix files, which may benefit future profiling studies using Drosophila.
format	article
author	Jack Cheng Lee-Fen Hsu Ying-Hsu Juan Hsin-Ping Liu Wei-Yong Lin
author_facet	Jack Cheng Lee-Fen Hsu Ying-Hsu Juan Hsin-Ping Liu Wei-Yong Lin
author_sort	Jack Cheng
title	Pathway-targeting gene matrix for Drosophila gene set enrichment analysis
title_short	Pathway-targeting gene matrix for Drosophila gene set enrichment analysis
title_full	Pathway-targeting gene matrix for Drosophila gene set enrichment analysis
title_fullStr	Pathway-targeting gene matrix for Drosophila gene set enrichment analysis
title_full_unstemmed	Pathway-targeting gene matrix for Drosophila gene set enrichment analysis
title_sort	pathway-targeting gene matrix for drosophila gene set enrichment analysis
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/733dcd8cdd1b4f8181bda0cfdeeb0b9f
work_keys_str_mv	AT jackcheng pathwaytargetinggenematrixfordrosophilagenesetenrichmentanalysis AT leefenhsu pathwaytargetinggenematrixfordrosophilagenesetenrichmentanalysis AT yinghsujuan pathwaytargetinggenematrixfordrosophilagenesetenrichmentanalysis AT hsinpingliu pathwaytargetinggenematrixfordrosophilagenesetenrichmentanalysis AT weiyonglin pathwaytargetinggenematrixfordrosophilagenesetenrichmentanalysis
_version_	1718445096879259648

Pathway-targeting gene matrix for Drosophila gene set enrichment analysis

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