Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.

Background: : The prevalence of depression with hypothyroidism is high. Objective: : To study the ability of aerobic exercise to improve hypothyroidism associated depression and to explore the underlying mechanisms. Materials and methods: 21 adult male rats, allocated in three groups; Euthyroid, Hyp...

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Autores principales:	Wessam Ezzat, Manal S. Abd-El Hamid
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hypothyroidism- depression- serotonin-irisin BDNF- aerobic exercise Mental healing RZ400-408
Acceso en línea:	https://doaj.org/article/733e97010aa84ebf989b2bcaddff9b37
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spelling	oai:doaj.org-article:733e97010aa84ebf989b2bcaddff9b372021-11-04T04:43:33ZAerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.2666-915310.1016/j.jadr.2021.100268https://doaj.org/article/733e97010aa84ebf989b2bcaddff9b372021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666915321001827https://doaj.org/toc/2666-9153Background: : The prevalence of depression with hypothyroidism is high. Objective: : To study the ability of aerobic exercise to improve hypothyroidism associated depression and to explore the underlying mechanisms. Materials and methods: 21 adult male rats, allocated in three groups; Euthyroid, Hypothyroid (oral propyl-thiouracil for 45 days), Exercise-treated hypothyroid group (30 minutes, swimming, 4 weeks). Forced swim test and histopathological brain examination were performed. Serum free T3, T4, TSH, irisin, brain neurochemical, oxidant-antioxidant and apoptotic markers were measured. Results: : Swimming exercise increased serum T3, T4, climbing and swimming times, brain serotonin, BDNF expression, glutathione peroxidase, antiapoptotic Bcl-2 and serum irisin levels and decreased TSH, immobility time, MDA, BAX/Bcl-2 ratio. Climbing time was positively correlated with BDNF, serotonin and T3. Conclusion: : Moderate aerobic exercise alleviated hypothyroidism-associated depression, via increased BDNF expression, which enhances hippocampal neurogenesis, serotonergic system activity and combat neuronal apoptosis.Wessam EzzatManal S. Abd-El HamidElsevierarticleHypothyroidism- depression- serotonin-irisinBDNF- aerobic exerciseMental healingRZ400-408ENJournal of Affective Disorders Reports, Vol 6, Iss , Pp 100268- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypothyroidism- depression- serotonin-irisin BDNF- aerobic exercise Mental healing RZ400-408
spellingShingle	Hypothyroidism- depression- serotonin-irisin BDNF- aerobic exercise Mental healing RZ400-408 Wessam Ezzat Manal S. Abd-El Hamid Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.
description	Background: : The prevalence of depression with hypothyroidism is high. Objective: : To study the ability of aerobic exercise to improve hypothyroidism associated depression and to explore the underlying mechanisms. Materials and methods: 21 adult male rats, allocated in three groups; Euthyroid, Hypothyroid (oral propyl-thiouracil for 45 days), Exercise-treated hypothyroid group (30 minutes, swimming, 4 weeks). Forced swim test and histopathological brain examination were performed. Serum free T3, T4, TSH, irisin, brain neurochemical, oxidant-antioxidant and apoptotic markers were measured. Results: : Swimming exercise increased serum T3, T4, climbing and swimming times, brain serotonin, BDNF expression, glutathione peroxidase, antiapoptotic Bcl-2 and serum irisin levels and decreased TSH, immobility time, MDA, BAX/Bcl-2 ratio. Climbing time was positively correlated with BDNF, serotonin and T3. Conclusion: : Moderate aerobic exercise alleviated hypothyroidism-associated depression, via increased BDNF expression, which enhances hippocampal neurogenesis, serotonergic system activity and combat neuronal apoptosis.
format	article
author	Wessam Ezzat Manal S. Abd-El Hamid
author_facet	Wessam Ezzat Manal S. Abd-El Hamid
author_sort	Wessam Ezzat
title	Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.
title_short	Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.
title_full	Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.
title_fullStr	Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.
title_full_unstemmed	Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.
title_sort	aerobic exercise mediated increase in bdnf expression ameliorates depression in propylthiouracil-induced hypothyroidism in adult rats.
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/733e97010aa84ebf989b2bcaddff9b37
work_keys_str_mv	AT wessamezzat aerobicexercisemediatedincreaseinbdnfexpressionamelioratesdepressioninpropylthiouracilinducedhypothyroidisminadultrats AT manalsabdelhamid aerobicexercisemediatedincreaseinbdnfexpressionamelioratesdepressioninpropylthiouracilinducedhypothyroidisminadultrats
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Aerobic Exercise Mediated Increase in BDNF Expression Ameliorates Depression in Propylthiouracil-Induced Hypothyroidism in Adult Rats.

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