Longitudinal hippocampal volumetric changes in mice following brain infarction

Abstract Hippocampal atrophy is increasingly described in many neurodegenerative syndromes in humans, including stroke and vascular cognitive impairment. However, the progression of brain volume changes after stroke in rodent models is poorly characterized. We aimed to monitor hippocampal atrophy oc...

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Autores principales:	Vanessa H. Brait, David K. Wright, Mohsen Nategh, Alexander Oman, Warda T. Syeda, Charlotte M. Ermine, Katrina R. O’Brien, Emilio Werden, Leonid Churilov, Leigh A. Johnston, Lachlan H. Thompson, Jess Nithianantharajah, Katherine A. Jackman, Amy Brodtmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/733fd8e8fe89434284c6d4ddeaa6db91
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spelling	oai:doaj.org-article:733fd8e8fe89434284c6d4ddeaa6db912021-12-02T16:50:17ZLongitudinal hippocampal volumetric changes in mice following brain infarction10.1038/s41598-021-88284-72045-2322https://doaj.org/article/733fd8e8fe89434284c6d4ddeaa6db912021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88284-7https://doaj.org/toc/2045-2322Abstract Hippocampal atrophy is increasingly described in many neurodegenerative syndromes in humans, including stroke and vascular cognitive impairment. However, the progression of brain volume changes after stroke in rodent models is poorly characterized. We aimed to monitor hippocampal atrophy occurring in mice up to 48-weeks post-stroke. Male C57BL/6J mice were subjected to an intraluminal filament-induced middle cerebral artery occlusion (MCAO). At baseline, 3-days, and 1-, 4-, 12-, 24-, 36- and 48-weeks post-surgery, we measured sensorimotor behavior and hippocampal volumes from T2-weighted MRI scans. Hippocampal volume—both ipsilateral and contralateral—increased over the life-span of sham-operated mice. In MCAO-subjected mice, different trajectories of ipsilateral hippocampal volume change were observed dependent on whether the hippocampus contained direct infarction, with a decrease in directly infarcted tissue and an increase in non-infarcted tissue. To further investigate these volume changes, neuronal and glial cell densities were assessed in histological brain sections from the subset of MCAO mice lacking hippocampal infarction. Our findings demonstrate previously uncharacterized changes in hippocampal volume and potentially brain parenchymal cell density up to 48-weeks in both sham- and MCAO-operated mice.Vanessa H. BraitDavid K. WrightMohsen NateghAlexander OmanWarda T. SyedaCharlotte M. ErmineKatrina R. O’BrienEmilio WerdenLeonid ChurilovLeigh A. JohnstonLachlan H. ThompsonJess NithianantharajahKatherine A. JackmanAmy BrodtmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanessa H. Brait David K. Wright Mohsen Nategh Alexander Oman Warda T. Syeda Charlotte M. Ermine Katrina R. O’Brien Emilio Werden Leonid Churilov Leigh A. Johnston Lachlan H. Thompson Jess Nithianantharajah Katherine A. Jackman Amy Brodtmann Longitudinal hippocampal volumetric changes in mice following brain infarction
description	Abstract Hippocampal atrophy is increasingly described in many neurodegenerative syndromes in humans, including stroke and vascular cognitive impairment. However, the progression of brain volume changes after stroke in rodent models is poorly characterized. We aimed to monitor hippocampal atrophy occurring in mice up to 48-weeks post-stroke. Male C57BL/6J mice were subjected to an intraluminal filament-induced middle cerebral artery occlusion (MCAO). At baseline, 3-days, and 1-, 4-, 12-, 24-, 36- and 48-weeks post-surgery, we measured sensorimotor behavior and hippocampal volumes from T2-weighted MRI scans. Hippocampal volume—both ipsilateral and contralateral—increased over the life-span of sham-operated mice. In MCAO-subjected mice, different trajectories of ipsilateral hippocampal volume change were observed dependent on whether the hippocampus contained direct infarction, with a decrease in directly infarcted tissue and an increase in non-infarcted tissue. To further investigate these volume changes, neuronal and glial cell densities were assessed in histological brain sections from the subset of MCAO mice lacking hippocampal infarction. Our findings demonstrate previously uncharacterized changes in hippocampal volume and potentially brain parenchymal cell density up to 48-weeks in both sham- and MCAO-operated mice.
format	article
author	Vanessa H. Brait David K. Wright Mohsen Nategh Alexander Oman Warda T. Syeda Charlotte M. Ermine Katrina R. O’Brien Emilio Werden Leonid Churilov Leigh A. Johnston Lachlan H. Thompson Jess Nithianantharajah Katherine A. Jackman Amy Brodtmann
author_facet	Vanessa H. Brait David K. Wright Mohsen Nategh Alexander Oman Warda T. Syeda Charlotte M. Ermine Katrina R. O’Brien Emilio Werden Leonid Churilov Leigh A. Johnston Lachlan H. Thompson Jess Nithianantharajah Katherine A. Jackman Amy Brodtmann
author_sort	Vanessa H. Brait
title	Longitudinal hippocampal volumetric changes in mice following brain infarction
title_short	Longitudinal hippocampal volumetric changes in mice following brain infarction
title_full	Longitudinal hippocampal volumetric changes in mice following brain infarction
title_fullStr	Longitudinal hippocampal volumetric changes in mice following brain infarction
title_full_unstemmed	Longitudinal hippocampal volumetric changes in mice following brain infarction
title_sort	longitudinal hippocampal volumetric changes in mice following brain infarction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/733fd8e8fe89434284c6d4ddeaa6db91
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Longitudinal hippocampal volumetric changes in mice following brain infarction

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