Current and Potential Therapies Targeting Inflammation in NASH

Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipot...

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Autores principales:	Somaya Albhaisi, Mazen Noureddin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	non-alcoholic steatohepatitis inflammation treatment macrophages lymphocytes cytokines Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/7345f67eb6464a7a90156f0596a25a7b
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spelling	oai:doaj.org-article:7345f67eb6464a7a90156f0596a25a7b2021-12-03T05:23:31ZCurrent and Potential Therapies Targeting Inflammation in NASH1664-239210.3389/fendo.2021.767314https://doaj.org/article/7345f67eb6464a7a90156f0596a25a7b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.767314/fullhttps://doaj.org/toc/1664-2392Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipotoxicity, immune responses, oxidative stress and cell death) and extrahepatic sources (adipose tissue or gut). The identification of triggers of inflammation is central to understanding the mechanisms in NASH development and progression and in designing targeted therapies that can halt or reverse the disease. In this review, we summarize the current and potential therapies targeting inflammation in NASH.Somaya AlbhaisiMazen NoureddinFrontiers Media S.A.articlenon-alcoholic steatohepatitisinflammationtreatmentmacrophageslymphocytescytokinesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-alcoholic steatohepatitis inflammation treatment macrophages lymphocytes cytokines Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	non-alcoholic steatohepatitis inflammation treatment macrophages lymphocytes cytokines Diseases of the endocrine glands. Clinical endocrinology RC648-665 Somaya Albhaisi Mazen Noureddin Current and Potential Therapies Targeting Inflammation in NASH
description	Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease (NAFLD). It is characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. Inflammation plays a key role in the progression of NASH and can be provoked by intrahepatic (e.g., lipotoxicity, immune responses, oxidative stress and cell death) and extrahepatic sources (adipose tissue or gut). The identification of triggers of inflammation is central to understanding the mechanisms in NASH development and progression and in designing targeted therapies that can halt or reverse the disease. In this review, we summarize the current and potential therapies targeting inflammation in NASH.
format	article
author	Somaya Albhaisi Mazen Noureddin
author_facet	Somaya Albhaisi Mazen Noureddin
author_sort	Somaya Albhaisi
title	Current and Potential Therapies Targeting Inflammation in NASH
title_short	Current and Potential Therapies Targeting Inflammation in NASH
title_full	Current and Potential Therapies Targeting Inflammation in NASH
title_fullStr	Current and Potential Therapies Targeting Inflammation in NASH
title_full_unstemmed	Current and Potential Therapies Targeting Inflammation in NASH
title_sort	current and potential therapies targeting inflammation in nash
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7345f67eb6464a7a90156f0596a25a7b
work_keys_str_mv	AT somayaalbhaisi currentandpotentialtherapiestargetinginflammationinnash AT mazennoureddin currentandpotentialtherapiestargetinginflammationinnash
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Current and Potential Therapies Targeting Inflammation in NASH

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