Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.

To date, most studies of white matter changes in Bipolar Disorder (BD) have been conducted in older subjects and with well-established disorders. Studies of young people who are closer to their illness onset may help to identify core neurobiological characteristics and separate these from consequenc...

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Autores principales:	Jim Lagopoulos, Daniel F Hermens, Sean N Hatton, Juliette Tobias-Webb, Kristi Griffiths, Sharon L Naismith, Elizabeth M Scott, Ian B Hickie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/73470cc5f514445f90de87a63d740038
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spelling	oai:doaj.org-article:73470cc5f514445f90de87a63d7400382021-11-18T07:52:54ZMicrostructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.1932-620310.1371/journal.pone.0059108https://doaj.org/article/73470cc5f514445f90de87a63d7400382013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527101/?tool=EBIhttps://doaj.org/toc/1932-6203To date, most studies of white matter changes in Bipolar Disorder (BD) have been conducted in older subjects and with well-established disorders. Studies of young people who are closer to their illness onset may help to identify core neurobiological characteristics and separate these from consequences of repeated illness episodes or prolonged treatment. Diffusion tensor imaging (DTI) was used to examine white matter microstructural changes in 58 young patients with BD (mean age 23 years; range 16-30 years) and 40 controls. Whole brain voxelwise measures of fractional anisotropy (FA), parallel diffusivity (λ//) and radial diffusivity (λ⊥) were calculated for all subjects. White matter microstructure differences (decreased FA corrected p<.05) were found between the patients with BD and controls in the genu, body and splenium of the corpus callosum as well as the superior and anterior corona radiata. In addition, significantly increased radial diffusivity (p<.01) was found in the BD group. Neuroimaging studies of young patients with BD may help to clarify neurodevelopmental aspects of the illness and for identifying biomarkers of disease onset and progression. Our findings provide evidence of microstructural white matter changes early in the course of illness within the corpus callosum and the nature of these changes suggest they are associated with abnormalities in the myelination of axons.Jim LagopoulosDaniel F HermensSean N HattonJuliette Tobias-WebbKristi GriffithsSharon L NaismithElizabeth M ScottIan B HickiePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59108 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jim Lagopoulos Daniel F Hermens Sean N Hatton Juliette Tobias-Webb Kristi Griffiths Sharon L Naismith Elizabeth M Scott Ian B Hickie Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.
description	To date, most studies of white matter changes in Bipolar Disorder (BD) have been conducted in older subjects and with well-established disorders. Studies of young people who are closer to their illness onset may help to identify core neurobiological characteristics and separate these from consequences of repeated illness episodes or prolonged treatment. Diffusion tensor imaging (DTI) was used to examine white matter microstructural changes in 58 young patients with BD (mean age 23 years; range 16-30 years) and 40 controls. Whole brain voxelwise measures of fractional anisotropy (FA), parallel diffusivity (λ//) and radial diffusivity (λ⊥) were calculated for all subjects. White matter microstructure differences (decreased FA corrected p<.05) were found between the patients with BD and controls in the genu, body and splenium of the corpus callosum as well as the superior and anterior corona radiata. In addition, significantly increased radial diffusivity (p<.01) was found in the BD group. Neuroimaging studies of young patients with BD may help to clarify neurodevelopmental aspects of the illness and for identifying biomarkers of disease onset and progression. Our findings provide evidence of microstructural white matter changes early in the course of illness within the corpus callosum and the nature of these changes suggest they are associated with abnormalities in the myelination of axons.
format	article
author	Jim Lagopoulos Daniel F Hermens Sean N Hatton Juliette Tobias-Webb Kristi Griffiths Sharon L Naismith Elizabeth M Scott Ian B Hickie
author_facet	Jim Lagopoulos Daniel F Hermens Sean N Hatton Juliette Tobias-Webb Kristi Griffiths Sharon L Naismith Elizabeth M Scott Ian B Hickie
author_sort	Jim Lagopoulos
title	Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.
title_short	Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.
title_full	Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.
title_fullStr	Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.
title_full_unstemmed	Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.
title_sort	microstructural white matter changes in the corpus callosum of young people with bipolar disorder: a diffusion tensor imaging study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/73470cc5f514445f90de87a63d740038
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Microstructural white matter changes in the corpus callosum of young people with Bipolar Disorder: a diffusion tensor imaging study.

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