Computed tomography structural lung changes in discordant airflow limitation.
<h4>Background</h4>There is increasing evidence that structural lung changes may be present before the occurrence of airflow limitation as assessed by spirometry. This study investigated the prevalence of computed tomography (CT) quantified emphysema, airway wall thickening and gas trapp...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/734908fe4eff46fdb591d61e4d44eae8 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:734908fe4eff46fdb591d61e4d44eae8 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:734908fe4eff46fdb591d61e4d44eae82021-11-18T07:41:57ZComputed tomography structural lung changes in discordant airflow limitation.1932-620310.1371/journal.pone.0065177https://doaj.org/article/734908fe4eff46fdb591d61e4d44eae82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785411/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>There is increasing evidence that structural lung changes may be present before the occurrence of airflow limitation as assessed by spirometry. This study investigated the prevalence of computed tomography (CT) quantified emphysema, airway wall thickening and gas trapping according to classification of airflow limitation (FEV1/FVC <70% and/or < the lower limit of normal (LLN)) in (heavy) smokers.<h4>Methods</h4>A total number of 1,140 male former and current smokers participating in a lung cancer screenings trial (NELSON) were included and underwent chest CT scanning and spirometry. Emphysema was quantified by the 15(th) percentile, air way wall thickening by the square root of wall area for a theoretical airway with 10mm lumen perimeter (Pi10) and gas trapping by the mean lung density expiratory/inspiratory (E/I)-ratio. Participants were classified by entry FEV1/FVC: group 1>70%; group 2<70% but >LLN; and group 3<LLN. 32 restricted subjects, i.e. FEV1/FVC >70% but FEV1 <80% predicted, were excluded. Multivariate regression analysis correcting for covariates was used to asses the extent of emphysema, airway wall thickening and gas trapping according to three groups of airflow limitation.<h4>Results</h4>Mean (standard deviation) age was 62.5 (5.2) years and packyears smoked was 41.0 (18.0). Group 2 subjects when compared to group 1 had a significantly lower 15(th) percentile, -920.6 HU versus -912.2 HU; a higher Pi10, 2.87 mm versus 2.57 mm; and a higher E/I-ratio, 88.6% versus 85.6% (all p<0.001).<h4>Conclusion</h4>Subjects with an FEV1/FVC<70%, but above the LLN, have a significant greater degree of structural lung changes on CT compared to subjects without airflow limitation.Firdaus A A Mohamed HoeseinPim A de JongJan-Willem J LammersWillem Pthm MaliMichael SchmidtHarry J de KoningCarlijn van der AalstMatthijs OudkerkRozemarijn VliegenthartBram van GinnekenEva M van RikxoortPieter ZanenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65177 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Firdaus A A Mohamed Hoesein Pim A de Jong Jan-Willem J Lammers Willem Pthm Mali Michael Schmidt Harry J de Koning Carlijn van der Aalst Matthijs Oudkerk Rozemarijn Vliegenthart Bram van Ginneken Eva M van Rikxoort Pieter Zanen Computed tomography structural lung changes in discordant airflow limitation. |
| description |
<h4>Background</h4>There is increasing evidence that structural lung changes may be present before the occurrence of airflow limitation as assessed by spirometry. This study investigated the prevalence of computed tomography (CT) quantified emphysema, airway wall thickening and gas trapping according to classification of airflow limitation (FEV1/FVC <70% and/or < the lower limit of normal (LLN)) in (heavy) smokers.<h4>Methods</h4>A total number of 1,140 male former and current smokers participating in a lung cancer screenings trial (NELSON) were included and underwent chest CT scanning and spirometry. Emphysema was quantified by the 15(th) percentile, air way wall thickening by the square root of wall area for a theoretical airway with 10mm lumen perimeter (Pi10) and gas trapping by the mean lung density expiratory/inspiratory (E/I)-ratio. Participants were classified by entry FEV1/FVC: group 1>70%; group 2<70% but >LLN; and group 3<LLN. 32 restricted subjects, i.e. FEV1/FVC >70% but FEV1 <80% predicted, were excluded. Multivariate regression analysis correcting for covariates was used to asses the extent of emphysema, airway wall thickening and gas trapping according to three groups of airflow limitation.<h4>Results</h4>Mean (standard deviation) age was 62.5 (5.2) years and packyears smoked was 41.0 (18.0). Group 2 subjects when compared to group 1 had a significantly lower 15(th) percentile, -920.6 HU versus -912.2 HU; a higher Pi10, 2.87 mm versus 2.57 mm; and a higher E/I-ratio, 88.6% versus 85.6% (all p<0.001).<h4>Conclusion</h4>Subjects with an FEV1/FVC<70%, but above the LLN, have a significant greater degree of structural lung changes on CT compared to subjects without airflow limitation. |
| format |
article |
| author |
Firdaus A A Mohamed Hoesein Pim A de Jong Jan-Willem J Lammers Willem Pthm Mali Michael Schmidt Harry J de Koning Carlijn van der Aalst Matthijs Oudkerk Rozemarijn Vliegenthart Bram van Ginneken Eva M van Rikxoort Pieter Zanen |
| author_facet |
Firdaus A A Mohamed Hoesein Pim A de Jong Jan-Willem J Lammers Willem Pthm Mali Michael Schmidt Harry J de Koning Carlijn van der Aalst Matthijs Oudkerk Rozemarijn Vliegenthart Bram van Ginneken Eva M van Rikxoort Pieter Zanen |
| author_sort |
Firdaus A A Mohamed Hoesein |
| title |
Computed tomography structural lung changes in discordant airflow limitation. |
| title_short |
Computed tomography structural lung changes in discordant airflow limitation. |
| title_full |
Computed tomography structural lung changes in discordant airflow limitation. |
| title_fullStr |
Computed tomography structural lung changes in discordant airflow limitation. |
| title_full_unstemmed |
Computed tomography structural lung changes in discordant airflow limitation. |
| title_sort |
computed tomography structural lung changes in discordant airflow limitation. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/734908fe4eff46fdb591d61e4d44eae8 |
| work_keys_str_mv |
AT firdausaamohamedhoesein computedtomographystructurallungchangesindiscordantairflowlimitation AT pimadejong computedtomographystructurallungchangesindiscordantairflowlimitation AT janwillemjlammers computedtomographystructurallungchangesindiscordantairflowlimitation AT willempthmmali computedtomographystructurallungchangesindiscordantairflowlimitation AT michaelschmidt computedtomographystructurallungchangesindiscordantairflowlimitation AT harryjdekoning computedtomographystructurallungchangesindiscordantairflowlimitation AT carlijnvanderaalst computedtomographystructurallungchangesindiscordantairflowlimitation AT matthijsoudkerk computedtomographystructurallungchangesindiscordantairflowlimitation AT rozemarijnvliegenthart computedtomographystructurallungchangesindiscordantairflowlimitation AT bramvanginneken computedtomographystructurallungchangesindiscordantairflowlimitation AT evamvanrikxoort computedtomographystructurallungchangesindiscordantairflowlimitation AT pieterzanen computedtomographystructurallungchangesindiscordantairflowlimitation |
| _version_ |
1718423105219592192 |